Dr. Xudong Li's research lab focuses on understanding how certain cellular processes affect the function and fitness of regulatory T cells, which are essential for maintaining a healthy immune response. The lab particularly investigates the role of heme synthesis, an important biological process, in controlling these T cells' abilities to prevent autoimmune diseases. By studying the effects of a specific enzyme on Treg cells, the goal is to develop new therapies that could enhance the body's natural defenses against autoimmune disorders.

Dr. Maribel Rios' lab studies how specific brain signals affect our body's energy and glucose management. Particularly, they focus on the relationship between two proteins, thrombospondin and a2d-1, in the brain regions that control eating and metabolism. By understanding how these proteins work, the lab hopes to find new ways to treat obesity and related metabolic diseases.

Cammie Lesser's lab at Tufts University focuses on understanding how the bacterium Shigella survives and replicates inside human intestinal cells. By studying how Shigella manipulates the immune system, particularly through inflammatory cell death processes, the lab aims to uncover new strategies for preventing and treating severe infections caused by this pathogen. This research is vital, especially in light of rising antibiotic resistance.

Dr. Klemen Strle's lab focuses on understanding Lyme disease, particularly why it affects people differently. They research the role of specific microbial proteins in causing excessive inflammation, which can lead to severe symptoms and complications. By studying these proteins in both human samples and mouse models, they aim to identify potential biomarkers for patients at risk of more severe disease and develop better treatment strategies.

Dr. Sam R Telford's lab focuses on enhancing biosafety and biocontainment in research related to infectious diseases. The team trains staff in advanced technical skills required for working with dangerous pathogens and develops resources to enable rapid responses to emerging health threats, such as pandemics. By fostering collaboration with academic and industry partners, the lab aims to improve regional preparedness in managing public health challenges.

Dr. Harry P. Selker leads the Tufts Clinical and Translational Science Institute, which focuses on enhancing clinical research and improving public health through innovative team science. The lab works with various partners to train new researchers, develop groundbreaking methods, and foster collaboration throughout the research continuum. Their ultimate goal is to bridge the gap between scientific research and practical health solutions.

Dr. Helen Suh's research lab focuses on understanding how extreme weather events affect community health and resilience, particularly in coastal regions of the southeastern United States. Her lab also investigates the role of airborne metals and fine particulate matter in contributing to neurodegeneration and dementia. By leveraging interdisciplinary methods, the lab aims to provide insights that can inform public health strategies and interventions for vulnerable communities.

Dr. Elizabeth A White's lab at Tufts University focuses on understanding how high-risk human papillomavirus (HPV) manipulates host cell signaling to promote persistent infections and contribute to cancer development. By studying the viral proteins E6 and E7, the lab explores their roles in cellular transformation, including how they disrupt signaling pathways that normally regulate cell growth and differentiation. This research aims to uncover mechanisms that could lead to new therapeutic strategies for HPV-related cancers.

Dr. Yi-Pin Lin's lab focuses on understanding how wild birds help maintain Lyme disease bacteria, which is a significant health concern in the U.S. The research aims to uncover the immune responses of birds that allow these bacteria to persist without causing the birds harm. By studying this interaction, the lab hopes to inform public health strategies to reduce the risk of Lyme disease in humans.