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Xin Yu — Dr. Xin Yu's lab at Case Western Reserve University focuses on understanding and improving recovery after a stroke. The lab develops advanced MRI techniques to study how fluid moves in the brain and how a protein called AQP4 contributes to brain edema during stroke recovery. This research aims to provide new insights that could lead to better treatments for patients recovering from strokes.
Yan Li — Dr. Yan Li's lab focuses on understanding pancreatic beta-cell biology and its implications for diabetes. They study how variations in genetic factors, particularly the gene HNF1A, affect the development and function of these cells. By using advanced techniques like single-cell genomic analyses, they aim to develop better strategies for generating functional beta-cells from stem cells, which could be crucial for diabetes therapies.
Yong Chen — Dr. Yong Chen's lab focuses on improving cancer diagnosis and treatment monitoring using advanced MRI techniques, specifically Magnetic Resonance Fingerprinting (MRF). The lab aims to develop non-invasive methods for predicting treatment responses in breast cancer and characterizing renal cell carcinoma. By utilizing innovative imaging biomarkers, the research seeks to personalize and enhance patient care while reducing unnecessary procedures and associated healthcare costs.
Jonathan Karn — Dr. Jonathan Karn's lab at Case Western Reserve University focuses on understanding how HIV persists in the body, particularly in the brain, and how different factors, such as RNA modifications and substance use, influence this process. The lab works to develop new methods for studying HIV latency and reactivation using advanced techniques such as next-generation sequencing and induced pluripotent stem cells. By deciphering the complex interactions between HIV and the brain, the lab aims to contribute to better treatments for HIV-associated neurocognitive disorders.
Xin Qi — Dr. Xin Qi's lab focuses on understanding the underlying mechanisms of neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The lab investigates proteins that influence neuronal health, mitochondrial function, and lipid metabolism, aiming to identify new therapeutic targets that could lead to effective treatments. Overall, their research strives to uncover how disruptions in these processes contribute to disease progression and cognitive deficits.
Theresa Torres Pizarro — Dr. Theresa Torres Pizarro's lab focuses on understanding the role of a protein called gasdermin B (GSDMB) in inflammatory bowel disease (IBD). The team investigates how different forms of GSDMB might affect the function of cells in the gut, especially during diseases like IBD. The ultimate goal is to uncover new ways to improve gut healing and develop treatments for IBD by exploring the molecular mechanisms of GSDMB.
Evan S Deneris — Dr. Evan Deneris's lab at Case Western Reserve University focuses on understanding how different types of serotonin neurons develop in the brain. They use advanced techniques to examine how genes and regulatory mechanisms shape these neurons and how disruptions in these processes could lead to neurodevelopmental disorders, like autism and depression. The lab combines expertise in molecular biology, genomics, and neuroscience to unravel these complex questions.
Norah C Feeny — Dr. Norah C. Feeny's lab focuses on understanding and improving psychological treatments for conditions like PTSD and depression, particularly in how individuals process stressful life events. The lab aims to develop innovative therapies that not only address negative emotional responses but also promote resilience and positive coping strategies. This research is vital because many existing treatments have high dropout rates and may not fully meet the needs of individuals suffering from these disorders.
Maria Hatzoglou — Dr. Maria Hatzoglou's lab focuses on how cells adapt to stress, specifically dehydration, by regulating protein synthesis. This research is important for understanding and treating diseases like diabetes and dry eye syndrome, which are linked to problems with cellular responses to stress. By studying how cells adjust their internal processes during dehydration, the lab aims to uncover new therapeutic strategies to improve cell survival in various health conditions.