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Stanley Perlman — Dr. Stanley Perlman's lab at the University of Iowa studies the long-term effects of COVID-19, focusing particularly on how it impacts the sense of smell and brain function. They investigate the relationship between inflammation and neurological issues after infection, aiming to uncover the mechanisms responsible for these symptoms. The research uses mouse models to explore how the virus and inflammatory responses affect olfactory and neurological health.
Ling Yang — Dr. Ling Yang's lab at the University of Iowa focuses on understanding how lysosomal dysfunction affects heart health, specifically in the context of heart failure with preserved ejection fraction (HFpEF). The lab uses innovative methods to study the role of lysosomes in controlling metabolic processes and inflammation in heart cells, aiming to uncover new therapeutic strategies for managing heart disease. Overall, the research will improve our understanding of the molecular mechanisms underlying cardiovascular health and disease.
Bing Li — Dr. Bing Li's lab focuses on understanding how a high fat diet leads to obesity and increases the risk of breast cancer. They study a protein called A-FABP, which plays a key role in this connection, particularly in how it interacts with immune cells and cancer cells. By uncovering these mechanisms, the lab aims to identify new ways to prevent breast cancer in individuals with obesity and evaluate A-FABP as a potential biomarker for monitoring breast cancer risk.
Grazyna Kochanska — Dr. Grazyna Kochanska's lab at the University of Iowa focuses on understanding the early parent-child relationships and how they influence children's socioemotional development. They explore why some children develop positive social behaviors while others may struggle with antisocial tendencies, looking closely at the interactions between temperament and parenting. Through extensive longitudinal studies, the lab aims to inform effective parenting interventions that can promote healthy development and prevent negative outcomes for children.
David S Weiss — Dr. David S. Weiss's lab focuses on understanding the structure and function of unique enzymes in the bacterium Clostridioides difficile, which is a major cause of antibiotic-associated diarrhea. By researching these enzymes, the lab aims to develop new antibiotics that target C. difficile without harming beneficial gut bacteria. This work is crucial for improving treatment outcomes and addressing public health issues related to bacterial infections.
John H Freeman — Dr. John H Freeman's research lab focuses on understanding how the cerebellum, a part of the brain traditionally associated with movement, also plays crucial roles in learning and cognition. Through studies in rats, the lab investigates how the cerebellum interacts with other brain regions, such as the anterior cingulate and hippocampus, to enhance learning processes. These findings aim to inform treatments for cognitive impairments related to neurological disorders.
John T Harty — Dr. John T. Harty's lab focuses on understanding how malaria impacts the immune system, particularly how prior exposure to the disease can hinder effective vaccination. The research primarily investigates CD8 T cell responses and the role of hemozoin, a byproduct of malaria infection, in compromising these immune responses. By studying these mechanisms, the lab aims to improve vaccine efficacy against malaria, especially in regions where the disease is endemic.
Kamal Rahmouni — Dr. Kamal Rahmouni's lab focuses on understanding the mechanisms behind hypertension, particularly how the brain regulates blood pressure under different conditions like obesity. They study unique structures in neurons called primary cilia, and how these cilia may contribute to high blood pressure and fluid balance. The lab uses advanced technologies to observe and manipulate brain neuron activity to gain insights into hypertension, aiming to develop new treatment strategies for cardiovascular diseases.
Vincent A Magnotta — Dr. Vincent A. Magnotta's lab at the University of Iowa focuses on using advanced imaging techniques to understand brain metabolism and its relation to neurological and psychiatric disorders, particularly Alzheimer’s disease and bipolar disorder. Their research aims to develop high-resolution imaging methods that can identify metabolic changes in the brain, helping to improve diagnosis, treatment, and understanding of these conditions. The lab's studies also explore the role of the cerebellum in mood regulation and suicidal behavior, contributing to the development of potential therapeutic strategies.