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Erik D Roberson — Dr. Erik D Roberson's lab at the University of Alabama at Birmingham focuses on understanding how disruptions in circadian rhythms affect brain function in relation to Alzheimer's disease. They investigate how changes in neuronal excitability, particularly in certain inhibitory neurons, may contribute to the disease's early stages. Through innovative techniques, the lab aims to uncover mechanisms linking circadian biology with cognitive impairment and develop potential therapeutic strategies.
Jianbo Wang — Dr. Jianbo Wang's lab at the University of Alabama at Birmingham focuses on understanding how a specific signaling molecule, Wnt5a, contributes to skeletal development and its associated disorders. They explore the molecular mechanisms of skeletal formation, particularly how mutations in the WNT5A gene lead to congenital skeletal diseases like Robinow syndrome. The lab uses various biochemical and genetic techniques to develop insights that could ultimately aid in regenerative medicine and therapies for skeletal disorders.
Christopher Ryan Miller — The Miller Lab focuses on developing new human glioma models to enhance precision treatment for brain tumors. They use advanced techniques to understand how these tumors function and resist therapies, helping to create targeted drug strategies. By collaborating with experts in various fields, the lab aims to improve options for patients suffering from gliomas, which are the most common and deadly brain cancer.
Bruce R Korf — Dr. Bruce Korf's lab at the University of Alabama at Birmingham focuses on diagnosing rare and chronic diseases in patients who have not been able to find answers through traditional medical avenues. The lab employs advanced genetics techniques, including genome sequencing, to identify underlying causes of these conditions. They also leverage innovative tools like artificial intelligence and telemedicine to enhance diagnostic efficiency and broaden access to necessary evaluations.
Jan Novak — Jan Novak's lab at the University of Alabama at Birmingham focuses on understanding the molecular mechanisms involved in IgA nephropathy (IgAN), a leading cause of kidney failure. The research aims to identify the characteristics and biological activities of IgA1-containing immune complexes in patients with this disease. By studying these complexes, the lab seeks to uncover the factors that influence disease progression and develop targeted therapies.
Jerzy P Szaflarski — Dr. Jerzy Szaflarski's lab at the University of Alabama at Birmingham specializes in understanding how neuroinflammation relates to temporal lobe epilepsy using advanced imaging techniques. The lab focuses on a new method known as magnetic resonance spectroscopic imaging and thermometry (MRSI-t) to visualize brain temperature changes, which can indicate underlying inflammation. By studying these processes, the lab aims to improve diagnosis and treatment strategies for individuals with epilepsy.
Jianyi Zhang — Dr. Jianyi Zhang's research focuses on understanding how heart cells can grow and repair themselves after injuries, like those caused by heart attacks. His lab studies various biological processes that allow these cells to re-enter the cycle of growth, with the goal of developing new therapies to regenerate heart tissue. By exploring innovative techniques such as genetic engineering and advanced cell culture methods, they aim to create solutions that could one day improve outcomes for heart patients.
Bradley K. Yoder — Dr. Bradley K. Yoder's research lab focuses on understanding the role of cilia and their associated proteins in kidney health and disease. Their work investigates how mutations in certain genes cause kidney cysts and how these cysts are influenced by injury and cellular repair processes. By using mouse models, the lab aims to uncover the mechanisms behind cyst formation and identify potential therapeutic strategies to better manage polycystic kidney disease (PKD).
Frances E. Lund — Dr. Frances E. Lund's research lab focuses on understanding the memory B and T cells of the human immune system, particularly in the context of organ transplantation. They investigate how these cells evolve and persist over time, especially in tissues vital for transplant success. Their work aims to uncover insights that could lead to improved treatments for transplant patients by balancing protective and damaging immune responses.