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Shilpa J Buch — Dr. Shilpa J Buch's lab at the University of Nebraska Medical Center focuses on understanding how HIV and substance abuse like cocaine affect the brain. Their research investigates the role of immune cells in the brain, especially how these cells respond to HIV proteins and drugs, leading to inflammation and cognitive decline. By studying processes like ferritinophagy, they aim to develop new treatments to improve brain health for people living with HIV and addiction.
Howard S Fox — Dr. Howard Fox's lab focuses on understanding how HIV and opioid use affect the brain on a cellular level. They use advanced techniques like single-cell RNA sequencing to examine how these factors interact and influence various brain cells. This research helps uncover important information about the neurological implications of HIV and drug abuse, with the potential to improve treatments and outcomes for affected individuals.
Paul D Fey — Dr. Paul D. Fey's lab focuses on understanding the mechanisms by which certain bacteria, specifically Staphylococcus species, adhere to human skin. Although some of these bacteria can cause infections, many also play beneficial roles by preventing other pathogens from colonizing the skin. The lab's research seeks to reveal how these bacteria interact with skin cells, which could lead to new treatments for infections.
Siddappa N Byrareddy — Dr. Siddappa N Byrareddy's lab at the University of Nebraska Medical Center focuses on understanding how substances like cocaine and cannabinoids influence the immune response and disease progression in HIV and related infections. They study the gut-brain connection and how factors like sex differences affect viral reservoirs and inflammation in the brain and intestines. The goal is to find better therapies for managing HIV/SIV and other chronic inflammatory conditions.
Tammy L Kielian — Dr. Tammy Kielian's lab focuses on understanding how immune cells, particularly T cells, interact with the bacterium Staphylococcus aureus during infections that can occur after brain surgeries like craniotomies. The lab investigates how these immune responses can both help and hinder the body's ability to eliminate biofilms formed by this bacteria, aiming to improve treatments for infections that can lead to serious complications.
Moorthy P. Ponnusamy — Dr. Moorthy P. Ponnusamy's lab at the University of Nebraska Medical Center focuses on understanding how specific sugar molecules on proteins, called truncated O-glycans, affect the spread of pancreatic cancer. They investigate how these sugar alterations influence cancer behavior and contribute to the aggressive nature of the disease. Their work aims to develop potential new treatments by manipulating these sugar structures.
Santhi Gorantla — Dr. Santhi Gorantla's lab at the University of Nebraska Medical Center focuses on understanding how HIV-1 persists in the central nervous system and how it can be attacked using new therapies. The lab studies immune cells that harbor the virus, particularly in the brain, to find out how drug use affects HIV's presence and the development of related neurological disorders. By using a specially developed mouse model that mimics human biology, the lab aims to develop strategies to eliminate HIV-1 from these reservoirs and improve treatment outcomes for patients.
Palsamy Periyasamy — Dr. Palsamy Periyasamy's lab at the University Of Nebraska Medical Center focuses on understanding the effects of HIV and methamphetamine on brain inflammation. They study how these substances activate astrocyte-specific inflammasomes, which are important for brain health. The ultimate aim is to identify new therapeutic targets to reduce neuroinflammation in individuals affected by HIV and drug abuse, improving their cognitive function and overall well-being.
Benson Edagwa — Benson Edagwa's lab focuses on creating innovative, long-acting drug formulations for the treatment of pediatric patients with HIV-1. Their main goal is to develop a six-month injectable antiretroviral therapy that improves adherence to treatment. By using advanced drug delivery methods, they aim to overcome the limitations of daily oral therapies, making it easier for children to receive life-saving HIV treatment.