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James V Haxby — James Haxby's research lab at Dartmouth College focuses on improving the analysis and sharing of functional brain imaging data using a method called hyperalignment. This technique helps resolve differences in brain activity patterns among individuals, allowing for better understanding of how various cognitive functions are represented in different brains. The lab aims to create a common platform for researchers in neuroscience to access and contribute valuable data, improving research on brain aging, cognitive processes, and clinical applications.
Keith D. Paulsen — Dr. Keith D. Paulsen's research lab focuses on improving breast cancer diagnosis through innovative imaging techniques. By combining near-infrared spectroscopic tomography (NIRST) with magnetic resonance imaging (MRI), the team seeks to create a diagnostic tool that does not require contrast injection or ionizing radiation. Their work aims to enhance the detection capabilities for breast abnormalities and contribute to better clinical management for patients.
Periannan Kuppusamy — Dr. Periannan Kuppusamy's lab at Dartmouth College is focused on developing innovative medical devices to improve cancer treatment. The primary project involves creating a specialized scanner that can measure the oxygen levels in tumors in real-time, which can help in planning better radiation therapy. This research combines engineering with clinical applications to enhance cancer care and monitor important health indicators.
Henry N Higgs — Dr. Henry N Higgs' lab at Dartmouth College studies the dynamic interplay between the actin cytoskeleton and mitochondria in mammalian cells. The team focuses on understanding how transient actin structures influence mitochondrial function and energy metabolism, particularly in relation to diseases linked to dysfunctional mitochondria. Their research has significant implications for various cellular processes and could lead to insights in treating conditions such as Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis.
Claudia V Jakubzick — Dr. Claudia V Jakubzick leads a research lab at Dartmouth College that focuses on understanding the role of mononuclear phagocytes in the immune system. Her lab compares the function and gene expression of these immune cells in both humans and mice to identify their similarities and differences. This work aims to improve our understanding of how these cells respond to infections and how this knowledge can be applied to develop better treatments for diseases.
James B Bliska — Dr. James B Bliska's lab at Dartmouth College studies how certain bacterial proteins can help pathogens avoid detection and destabilize the body's immune defenses. They focus on understanding how bacteria, like Yersinia, use specialized mechanisms to disrupt protective pathways in immune cells during infection. This research not only enhances our understanding of bacterial infections but also aims to inform new approaches to boost immune defenses against such pathogens.
Charles L. Sentman — Dr. Charles L. Sentman's lab at Dartmouth College focuses on developing innovative therapies for Alzheimer's disease using genetically engineered immune cells. The lab's main project involves creating chimeric antigen receptor (CAR) T regulatory cells that can target and clear harmful amyloid-beta protein plaques in the brain, while reducing inflammation associated with the disease. By enhancing the persistence and activity of these targeted cells, the goal is to improve treatments for Alzheimer's and its neurodegenerative effects.
Margaret E Ackerman — Dr. Margaret E Ackerman's lab at Dartmouth College focuses on novel antibody therapies to combat viral infections, specifically HIV and neonatal herpes simplex virus (nHSV). They explore how broadly neutralizing antibodies (bNAbs) can be engineered and optimized to enhance their effectiveness in preventing these infections. The research aims to translate these approaches into practical treatments that can significantly improve health outcomes for affected populations.
Surachai Supattapone — Dr. Surachai Supattapone's lab at Dartmouth College focuses on understanding prion diseases, which are caused by misfolded proteins that lead to neurodegenerative disorders such as Creutzfeldt-Jakob disease. The lab uses advanced genetic screening techniques to map the molecular pathways that control the metabolism of prion proteins, aiming to identify potential new targets for drug therapy. Their research not only enhances our knowledge of prion biology but also contributes to the development of therapeutic strategies for these fatal brain diseases.