Loading university
Joseph S Takahashi — Dr. Joseph S. Takahashi's lab at UT Southwestern Medical Center focuses on understanding how the timing of food intake affects aging and lifespan. Their research explores the concept of caloric restriction and its interactions with circadian rhythms, studying how these factors can promote healthier aging. The lab's work seeks to uncover the molecular mechanisms behind these processes, particularly the role of inflammation and specific genes in regulating longevity.
Joshua T Mendell — Dr. Joshua T Mendell's lab focuses on understanding how specific modifications to transfer RNA (tRNA) impact the growth and spread of clear cell renal cell carcinoma (ccRCC), a type of kidney cancer. The lab investigates a newly discovered mechanism where altered tRNA modifications can change the way cancer cells metabolize energy, potentially leading to increased metastasis. By combining expertise in RNA biology and cancer research, the lab seeks to uncover new therapeutic targets for treatment.
Jing Wang — Dr. Jing Wang's lab focuses on improving radiation therapy for patients with head and neck cancer by developing advanced predictive models to identify cancerous lymph nodes. They use machine learning techniques to analyze imaging data and patient information to enhance treatment efficacy while reducing side effects. The goal is to change how radiation is applied, making it more precise and minimizing harm to healthy tissues.
Steven L Mcknight — Dr. Steven L. McKnight's lab focuses on understanding how certain proteins, made up of a limited number of amino acids, play crucial roles in cellular functions. These proteins, known as low complexity domains, are often disordered and involved in various cellular processes, including the formation of RNA-rich structures in cells. The lab's research aims to uncover the mechanisms by which these proteins assemble and regulate cellular activities, with implications for understanding diseases like neurodegeneration.
Martin G Pomper — Dr. Martin G Pomper's lab specializes in developing innovative therapies and imaging techniques for prostate cancer, which is a significant health concern for men. They are focused on creating multimodal theranostic agents that combine diagnosis and treatment into one platform, particularly using dendrimers to target prostate-specific membrane antigen (PSMA). Their research aims to improve patient outcomes by enhancing the accuracy of cancer detection and monitoring treatment efficacy through advanced imaging methods.
Elan D Louis — Dr. Elan D. Louis's lab focuses on exploring essential tremor (ET), a common neurological condition that affects millions of Americans. The lab is investigating the use of PET imaging to measure a potential biomarker, synaptic vesicle glycoprotein 2A (SV2A), which may help diagnose ET and track its progression, a crucial development given the lack of current biomarkers for this disease. Their research not only aims to enhance diagnostic accuracy but also aims to differentiate ET from related movement disorders.
Qing Zhang — Dr. Qing Zhang's lab at UT Southwestern Medical Center focuses on understanding clear cell renal cell carcinoma (ccRCC), a highly aggressive form of kidney cancer that often metastasizes to the lungs. The lab uses advanced techniques like CRISPR screening and RNA sequencing to uncover the molecular mechanisms behind this cancer's progression and treatment resistance. Their research aims to identify new therapeutic targets that could improve survival outcomes for patients with metastatic kidney cancer.
Rong Zhang — Dr. Rong Zhang's lab at UT Southwestern Medical Center focuses on understanding how treating high blood pressure can affect brain health in older adults, particularly in relation to Alzheimer's disease. They investigate how lowering blood pressure can influence brain amyloid and tau levels, which are linked to dementia, as well as brain blood flow and overall cognitive function. The lab's research aims to provide insights that could lead to new methods for preventing and treating dementia in aging populations.
Andrew Zhuang Wang — Dr. Andrew Zhuang Wang's lab at UT Southwestern Medical Center focuses on creating advanced models to study how cancer spreads, particularly to specific organs. By engineering tissues that mimic these organs, they aim to understand the factors that influence metastasis and improve cancer treatment strategies. The lab's innovative approach combines biology and engineering to develop tools that could lead to breakthroughs in precision medicine for cancer patients.