Dr. Laurent Brossay's lab at Brown University focuses on understanding how the immune system responds to viral infections, particularly murine cytomegalovirus (MCMV), which shares similarities with the human version. They investigate how Natural Killer (NK) cells behave in salivary glands during infection, revealing how these cells can limit immune responses without harming tissue. The lab aims to uncover the mechanisms behind viral persistence and the delicate balance between fighting infections and preventing damage to the host.

Dr. Amanda Jamieson's lab at Brown University researches how the immune system responds to severe respiratory infections like influenza and bacterial pneumonia. They focus on a specific protein called Caspase-8, which helps regulate cell death in immune cells called macrophages. By studying these processes, the lab aims to find ways to improve treatments for infections that cause high rates of illness and death.

Dr. Sanghyun Lee's lab at Brown University focuses on understanding how viruses evade the immune responses of intestinal epithelial cells during infections. The research involves studying specific viral proteins that interact with cellular receptors to suppress immune signaling pathways. The lab aims to uncover the mechanisms behind these interactions to better understand enteric viral infections and potential therapeutic targets.

Dr. Lalit K Beura's lab at Brown University focuses on understanding how specific immune cells called CD8 T lymphocytes protect the female reproductive tract from viral infections. By investigating how these cells develop and maintain their protective functions, the lab aims to improve strategies for vaccine development against viral diseases affecting this important area of the body. The research combines advanced techniques like single-cell RNA sequencing and in vitro organoid systems to explore the complex biology of immune responses.

Dr. Shipra Vaishnava's lab at Brown University studies how vitamin A interacts with gut bacteria to influence immune health and gut barrier function. They explore the role of retinoic acid, a vitamin A metabolite, in regulating immune responses and epithelial regeneration, aiming to reveal new insights that could lead to dietary or microbial therapies for diseases involving gut barrier dysfunction.