Dr. Ari Rosenberg's lab at the University of Wisconsin-Madison focuses on understanding how primates perceive and interact with the three-dimensional (3D) world. By studying the neural circuits in the brain associated with visual processing and eye movements, the lab aims to uncover the underpinnings of 3D perception and its implications for both normal cognition and neurodevelopmental disorders. The research combines behavioral experiments and advanced techniques to provide insights relevant to both basic science and potential therapeutic applications.

Dr. Jose Francisco Abisambra's lab studies how a protein called tau affects memory and contributes to frontotemporal dementia (FTD). They investigate how abnormal tau interacts with cellular machinery that translates genetic information into proteins, which is crucial for brain function. By understanding this link, the lab aims to uncover potential therapeutic targets to help those affected by memory impairments related to dementias.

Dr. Merideth A. Addicott's lab at Wake Forest University focuses on understanding the long-term effects of electronic cigarettes on brain health. The research investigates how e-cig use compares to traditional cigarette smoking and its implications for cognitive function, brain structure, and overall physiological health in adult smokers. By exploring critical biomarkers and recovery measures, the lab aims to inform public health policies regarding smoking cessation and the relative safety of e-cigarettes.

Dr. Alison R. Preston's research focuses on understanding how specific brain areas develop during adolescence and how this relates to memory and reasoning abilities. By studying the hippocampus and frontoparietal cortex, her lab aims to uncover why memory becomes more complex as we age and how these changes might impact learning and mental health. The findings could lead to better strategies for supporting cognitive development in young people.

Dr. Dritan Agalliu's lab at Columbia University focuses on understanding traumatic brain injury (TBI) and its effects on the brain's blood-barrier system. Using advanced human cell models, particularly stem cells, the lab investigates how immune responses and blood components impact brain function after injury. They aim to develop innovative models that can help identify new biomarkers for TBI and test potential treatments to mitigate its effects.

The Dong lab at UCLA focuses on understanding how aging and Alzheimer's disease affect the brain at a cellular level. Using advanced techniques like single-cell RNA sequencing and 3D mapping, we study specific types of brain cells in mice to uncover the changes that occur as these animals age or develop Alzheimer's. Our research aims to create detailed brain atlases that can help scientists worldwide study neurodegenerative diseases more effectively.

Dr. Rashad Hussain's lab at the University of Rochester focuses on understanding how exposure to air pollution, specifically ultra-fine particles, affects brain health and contributes to Alzheimer's disease. The research investigates the glymphatic system, a vital pathway for clearing waste from the brain, and explores how its impairment may lead to cognitive decline and neuroinflammation. Through innovative mouse models and advanced imaging techniques, the lab aims to uncover the molecular mechanisms linking environmental toxicants to neurodegenerative diseases.

Dr. Marilyn S. Albert's lab conducts groundbreaking research on Alzheimer's disease, focusing on identifying biomarkers that indicate cognitive decline in individuals who are initially cognitively healthy. By tracking participants over several decades, the lab aims to uncover the earliest changes associated with Alzheimer's, paving the way for preventive measures and interventions. The research not only enhances our understanding of Alzheimer's progression but also looks into the role of lifestyle factors in cognitive health.

Dr. Rong Chen's lab focuses on understanding how chronic alcohol consumption affects brain function, particularly in the prefrontal cortex. The lab studies the relationship between alcohol exposure, cholesterol levels in the brain, and glutamate signaling, which is crucial for communication between neurons. By exploring these interactions, they aim to identify new targets for treating alcohol use disorders and associated behavioral issues like anxiety.

Dr. Danny Winder's research lab focuses on understanding how alcohol affects sleep and the brain's arousal pathways, especially in individuals with alcohol use disorders. Their work aims to uncover the complex mechanisms linking alcohol consumption with sleep disturbances, using advanced techniques to analyze how specific brain pathways are influenced by alcohol. This research is important for developing better treatments for sleep issues related to alcohol dependence.

Dr. David A. Kareken's lab focuses on understanding how inherited risks for alcohol use disorders (AUD) impact brain function, specifically looking at how brain connectivity changes during different mental states. The research aims to identify if these changes in brain networks contribute to difficulties in controlling behavior, especially in relation to alcohol consumption. By exploring these connections, the lab hopes to develop biomarkers that can help in the prevention and treatment of AUD.

Dr. Charles N. Allen's lab at Oregon Health & Science University studies the brain's master circadian clock located in the suprachiasmatic nucleus (SCN). They focus on how brain cells communicate to maintain our biological rhythms and how neurotransmitters like GABA affect these processes. By understanding these interactions, the lab aims to find solutions for health issues related to circadian rhythm disruptions, which can arise from modern lifestyle demands.

Dr. Stephen Goutman's lab at the University of Michigan focuses on understanding amyotrophic lateral sclerosis (ALS), a debilitating neurological condition, by investigating the role of the immune system and environmental exposures. The lab aims to develop diagnostic tools and therapeutic strategies based on immune signatures and occupational risks associated with ALS, utilizing advanced technologies like spectral flow cytometry to analyze immune profiles in patients. Their research seeks to enhance predictions of disease progression and inform prevention strategies for individuals at higher risk of developing ALS.

Dr. Richard P Mayeux's lab at Columbia University focuses on studying blood-based biomarkers for Alzheimer's Disease, particularly in diverse populations. They investigate how these biomarkers can help improve diagnosis and understanding of the disease, using innovative techniques and community-based studies. Their work aims to identify genetic risk factors and how various elements like age, sex, and race impact Alzheimer's diagnosis.

Dr. Joanna Jankowsky's lab at Washington University focuses on understanding the diverse biological mechanisms that contribute to the development and progression of Alzheimer's disease. By using specialized mouse models that express amyloid precursor protein in different types of neurons, the lab investigates how these variations influence amyloid plaque formation and the subsequent effects on cognitive function. The goal is to uncover the relationship between neuron behavior and Alzheimer's disease pathology, which may lead to improved therapeutic strategies.

Dr. Gao Wang's lab focuses on understanding the genetic and molecular basis of Alzheimer's Disease (AD) by using advanced computational methods and multi-omics data. They study how genetic variations affect RNA modifications and other molecular traits in brain cells, particularly in diverse populations such as African Americans and Hispanics. The ultimate goal is to identify specific genes and processes that contribute to AD, which may pave the way for new therapeutic strategies.

Dr. Michael D. Greicius's lab at Stanford University focuses on Alzheimer's disease, particularly the genetic factors that influence risk for the disease. Using advanced techniques like long-read sequencing, the lab explores how variations in the APOE gene and other relevant genes affect Alzheimer's risk in individuals of different ancestries. The ultimate goal is to identify new therapeutic targets that may lead to better treatments for this devastating disease.

Dr. David Alan Bennett's lab focuses on understanding the genetic and molecular factors that contribute to Alzheimer's disease and related dementias, especially in diverse populations, including those of African ancestry. The lab conducts extensive genomic analyses, including whole genome sequencing and admixture studies, to identify key genetic drivers of these diseases. By analyzing data from autopsied brain samples across Brazil and the USA, the research aims to uncover the complexities of Alzheimer's pathology and promote better health outcomes in affected communities.

Dr. Sarah Banks's lab focuses on understanding how biological and lifestyle factors contribute to the risk and progression of Alzheimer's Disease, particularly in women and underrepresented groups like Black women. The lab investigates how inflammation, insulin resistance, and physical activity influence tau pathology and cognitive decline. By studying these relationships, the lab aims to identify modifiable risk factors and therapeutic targets that can help in preventing or delaying Alzheimer’s disease, especially in populations that have been historically overlooked in research.

Dr. Randall J. Bateman's lab at Washington University focuses on understanding and diagnosing Alzheimer's Disease (AD) through innovative blood tests and longitudinal studies. The lab is part of the Dominantly Inherited Alzheimer Network (DIAN), which gathers essential data from individuals at high risk for AD, allowing researchers to track disease progression and develop new preventive strategies. By studying biomarkers like amyloid and tau in blood samples, the lab aims to improve early detection methods and inform future clinical trials for new Alzheimer's therapies.