Scott Pletcher's lab at the University of Michigan focuses on understanding how social interactions and environmental factors influence the aging process. Using fruit flies as a model organism, the lab develops advanced technologies to monitor behavior and analyze molecular changes over time. Their research aims to uncover the biological mechanisms behind social behaviors and their impact on aging, creating a foundation for future studies in other species, including humans.

Dr. Lei Yin's lab at the University of Michigan focuses on understanding how a protein called ChREBP protects the liver from fatty liver diseases, particularly non-alcoholic steatohepatitis (NASH). By investigating the role of ChREBP in regulating fat metabolism and cell behavior in the liver, the lab aims to uncover new approaches to prevent and treat serious liver conditions. This research is vital since NASH is a significant health concern with limited treatment options.

Dr. Ormond A. Macdougald's lab at the University of Michigan focuses on understanding the mechanisms behind lipodystrophy, a condition characterized by the loss of fat tissue. They study how mutations in the LMNA gene affect fat cells and related metabolic health in both mice and humans. The research aims to uncover the biological processes that lead to fat loss, particularly during puberty, and could potentially reveal new strategies for treating related metabolic disorders.

Dr. William E. Rainey’s lab at the University of Michigan focuses on understanding how the adrenal gland produces different hormones. They study the processes that lead to the formation of specific cell types in the adrenal cortex, particularly how progenitor cells develop into hormone-producing cells. The research aims to uncover the molecular mechanisms behind these transformations, which could help in understanding adrenal-related health issues.

Dr. Linda C. Samuelson's lab at the University of Michigan focuses on understanding how certain signaling pathways regulate gastric epithelial cells. Their research investigates the role of Wnt and retinoic acid in maintaining the stomach lining and how these pathways help repair tissue after injury. By studying these processes in both mouse models and human organoids, the lab aims to develop insights that could lead to new treatments for gastric diseases that involve cell overgrowth or damage.

Dr. Suzanne Moenter's lab at the University of Michigan studies how the brain regulates the release of hormones essential for fertility. They focus on the neurons that produce gonadotropin-releasing hormone (GnRH), an important hormone for reproductive health. By understanding how these neurons generate hormone pulses, the research aims to shed light on reasons behind fertility issues and potentially guide treatments for infertility.

Dr. Liangyou Rui's lab focuses on understanding the role of specific brain circuits in regulating body weight and metabolism, particularly in the context of obesity and metabolic diseases. The lab investigates how SH2B1, a signaling protein, influences these neural pathways and how disruptions can lead to disorders such as type 2 diabetes and fatty liver disease. Their research aims to develop new therapeutic strategies for treating obesity by mapping these intricate neurocircuits.

Jun Hee Lee's lab at the University of Michigan focuses on understanding the interplay between exercise, nutrition, and muscle health, particularly in the context of aging. They investigate how the protein Sestrins mediates the benefits of the amino acid leucine and exercise on maintaining muscle homeostasis, which is crucial for preserving mobility and overall health in older adults. Their research aims to clarify how these factors interact to inform better preventative strategies against muscle degeneration.

Dr. Susan V Brooks' lab at the University of Michigan focuses on understanding how muscle function can be preserved as people age. They study the role of Schwann cells—a type of cell that supports nerves—in helping muscles adapt when nerve connections are lost. Their research aims to identify the mechanisms that allow muscle fibers to survive and thrive, particularly in older adults, with the hope of developing new therapies to prevent muscle loss and enhance mobility in aging populations.