Dr. Gabor T Marth's lab focuses on improving how we detect somatic mutations, which are changes in our DNA that can lead to diseases like cancer. One key project is developing a software called RUFUS to enhance the sensitivity and accuracy of detecting these mutations across various types and frequencies. Another project, Calypso, aims to create a user-friendly web tool for clinical teams to collaborate on genomic diagnostics over time, particularly for complex cases like those in neonatal care and undiagnosed disease clinics.

Dr. Alphonsus Ng's lab focuses on understanding Type 1 Diabetes (T1D) by analyzing extracellular vesicles (EVs) released into the bloodstream. Their work involves developing advanced micro-nanotechnologies to identify potential biomarkers for T1D, which could lead to better diagnosis and treatment options. The lab combines expertise in immunology, molecular analysis, and engineering to study the unique molecular signatures from pancreatic islet cells and T cell activity in diabetes.

Dr. Stacey Lynn Clardy's lab focuses on treating and understanding N-methyl-D-aspartate receptor (NMDAR) encephalitis, a serious autoimmune brain disorder that can cause severe psychiatric and neurological problems. The lab is conducting clinical trials to evaluate a promising treatment using inebilizumab, a monoclonal antibody that targets specific immune cells. Their research aims not only to improve patient outcomes but also to identify predictive biomarkers for treatment responses.

Dr. Neng Wan's lab focuses on understanding how different social and environmental factors influence physical activity among Pacific Islanders in the United States. The research aims to uncover the reasons behind low physical activity levels in this group and develop strategies to promote healthier lifestyles. Using advanced technologies, the lab tracks real-time physical activity data to gain insights that could inform health policies and interventions.

Dr. Dennis L Parker's lab focuses on advancing magnetic resonance imaging (MRI) techniques for the evaluation and management of carotid artery disease. The lab collaborates with multiple centers to develop user-friendly, non-contrast MRI methods that can provide critical information about atherosclerosis without the need for complex procedures. The ultimate goal is to improve clinical practices and patient outcomes through innovative imaging and analysis techniques.

Allison Payne's research focuses on improving breast cancer treatments through non-invasive techniques. Her lab is exploring magnetic resonance guided focused ultrasound (MRgFUS) as a way to treat localized breast tumors while minimizing damage to surrounding tissues. By developing advanced imaging biomarkers and deep learning models, the lab aims to provide real-time assessments of tissue viability during treatment, ultimately enhancing treatment effectiveness and reducing overtreatment of patients.

Dr. Erika M. Pliner's research focuses on understanding how cognitive and motor processes influence the ability of older adults to engage in stepping-based exercises, which are crucial for fall prevention. With a rising older population experiencing increased fall rates, her lab aims to optimize exercise interventions by studying how age and task complexity affect stepping efficacy. By using innovative mobile EEG technology, the team seeks to uncover objective biomarkers that can help tailor interventions and improve safety and quality of life for seniors.

Dr. Tommaso Lenzi's research focuses on developing advanced lightweight powered prosthetics for individuals with above-knee amputations. The aim is to create prosthetic devices that are easier to use and can help amputees move more naturally and comfortably, improving their overall quality of life. This research seeks to not only enhance mobility but also to understand how various technologies in prosthetics can meet the needs of users in everyday environments.

Dr. Aaron R. Quinlan's lab focuses on creating innovative algorithms and tools to analyze large genomic datasets. As genomics research expands, existing methods struggle to keep up with the size and complexity of new data. The lab aims to enhance the capabilities of genome arithmetic, allowing researchers to effectively explore, compare, and visualize vast genomic information, thus facilitating new discoveries in the field.

Dr. Richard D. Rabbitt's lab focuses on studying benign paroxysmal positional vertigo (BPPV), a common cause of dizziness caused by dislodged particles in the inner ear. The research includes creating advanced models to simulate how these particles affect balance and exploring new methods to improve diagnosis and treatment for patients with this condition. By combining computational modeling with experimental techniques, the lab aims to better understand the mechanics of the inner ear and develop more effective clinical approaches.

Dr. Nichole L Link's lab focuses on understanding how certain RNA-binding proteins influence brain development and are connected to neurodevelopmental disorders like autism. They investigate the role of these proteins in stabilizing important mRNA molecules in neurons, which is crucial for proper brain formation. The lab uses advanced genetic models, including fruit flies and mouse cultures, to study these mechanisms and their implications for human diseases.

Dr. Saveez Saffarian's lab focuses on understanding how the HIV virus assembles and matures into an infectious form. By exploring the molecular structure and dynamics of the immature HIV lattice, the lab seeks to develop new antiviral therapies that inhibit this maturation process. Students will engage in cutting-edge biophysical imaging and computational methodologies to analyze complex biological systems.

Dr. Kelly T. Hughes' lab at the University of Utah focuses on understanding how bacteria, particularly Salmonella, use specialized structures called injectisomes to infect host cells. By studying the intricate processes that allow these bacteria to deliver harmful proteins into cells, the lab aims to develop new ways to combat bacterial infections and address the growing problem of antimicrobial resistance. The research not only sheds light on basic biological mechanisms but also seeks to uncover potential targets for new therapeutic strategies.

Dr. Oleksandr Shcheglovitov's lab focuses on creating and studying human brain organoids that mimic the connections in the cortico-striatal network, which is affected in various brain disorders such as Parkinson's disease and autism. The lab aims to develop a reliable method for generating these organoids from stem cells to investigate how these neural networks mature and function, as well as the cellular mechanisms at play. This research may lead to new insights and therapies for brain disorders impacting connectivity.

Dr. Moriel Zelikowsky's lab focuses on understanding how social isolation impacts aggression through brain mechanisms. By studying the medial prefrontal cortex and specific neuron types, the lab aims to uncover how these brain circuits can lead to increased aggression and insight into potential treatments for related mental health issues. This research is particularly relevant in light of growing societal concerns about aggression and violence driven by social isolation.

The lab of Dr. Wesley I. Sundquist at the University of Utah focuses on understanding the molecular mechanisms behind HIV-1 virus assembly and release from host cells. By studying the roles of specific host proteins and cellular pathways, the research aims to identify how HIV-1 exploits these mechanisms and how certain proteins can inhibit viral release. This research not only targets HIV but also provides insights into other enveloped viruses and potential therapeutic strategies against viral infections.

Dr. Brian D. Evavold's lab focuses on understanding how T cell receptors (TCRs) recognize antigens and how this interaction influences immune responses, particularly in autoimmune diseases like multiple sclerosis. By studying the physical properties of TCRs, such as bond lifetime and force, the lab aims to reveal critical information about T cell behavior and function. This research has the potential to lead to new therapies for autoimmune conditions by improving our understanding of how T cells can be regulated during immune responses.

Dr. Daniel R. Scoles' lab focuses on understanding how certain kinases, particularly PASK, regulate cell processes and contribute to neurodegenerative diseases like ALS and FTD. They investigate the roles of protein modifications and genetic interactions, aiming to develop new therapeutic strategies. The research combines genetic models and cell studies to pave the way for potential treatments.

Dr. Erhu Cao's lab focuses on understanding the structures and functions of proteins related to polycystic kidney disease and cation-chloride cotransporters, which play important roles in kidney function and brain activity. By studying these proteins, the lab aims to uncover mechanisms behind genetic disorders and explore new ways to treat conditions like hypertension, edema, and congenital heart defects. The research combines biochemical and structural analysis to inform the development of targeted therapies.

Dr. Cynthia A Berg's research lab focuses on improving the management of Type 1 diabetes (T1D) during the challenging transition to adulthood. Her team explores how to enhance self-regulation strategies and leverage social support networks to help young adults aged 18-24 better manage their diabetes. The lab investigates a newly adapted intervention aimed at equipping emerging adults with skills for effective diabetes management and supports their ability to build relationships and communicate needs as they transition out of parental guidance.