Dr. Cherie L Marvel's lab studies how Lyme disease affects the brain, particularly after treatment when some patients experience lingering neurological symptoms. They investigate the relationship between changes in brain structure, specifically white matter, and cognitive performance over time. By using advanced imaging techniques and blood tests, the lab aims to uncover the biological mechanisms behind these cognitive issues, potentially leading to better diagnostic and therapeutic strategies for patients.

Dr. Xiaobo Mao's lab at Johns Hopkins University investigates how environmental pollutants, specifically air pollution, may contribute to the development of dementia, including Lewy Body Dementia and Alzheimer's Disease. The lab focuses on understanding the mechanisms through which these pollutants affect the brain and lead to cognitive decline. They explore the role of proteins related to neurodegenerative diseases, aiming to identify potential biomarkers for early diagnosis and treatment strategies.

Dr. Elisabeth Breese Marsh's lab at Johns Hopkins University focuses on understanding and addressing vascular cognitive impairment in patients who have experienced minor strokes. The research aims to identify noninvasive digital biomarkers to predict cognitive decline, leveraging advanced neuroimaging techniques like magnetoencephalography (MEG) and electroencephalography (EEG) combined with deep learning methods. Ultimately, their goal is to develop tools that can help identify patients at risk for cognitive impairment after stroke, leading to timely interventions that could improve patient outcomes.

Dr. Mark A. Marzinke's lab at Johns Hopkins University focuses on HIV prevention through innovative laboratory research and support for clinical trials. The lab plays a crucial role in the HIV Prevention Trials Network, leading efforts to evaluate and implement new strategies for preventing HIV infection, including drug development and testing methodologies. With an emphasis on quality assurance and collaboration across various stakeholders, the lab aims to identify effective and scalable interventions to combat the HIV/AIDS epidemic.

Dr. Andrew S. Mccallion's lab at Johns Hopkins University focuses on understanding how genetic variations in noncoding DNA affect the risk and progression of Parkinson's disease (PD). They aim to investigate the regulatory changes in brain cells that contribute to PD by studying gene regulation and expression in dopamine neurons. Through advanced computational and experimental techniques, the lab seeks to uncover the mechanisms that link genetic factors to disease outcomes, which could inform future treatments and interventions.

Dr. Alan Keith Meeker's lab at Johns Hopkins University focuses on understanding prostate cancer treatment responses by investigating a telomere biomarker. This research aims to determine which patients might benefit from additional therapies after prostate surgery, helping to personalize and improve treatment decisions. By using advanced analysis of tumor biology, the lab seeks to identify patients who would either not benefit from aggressive treatments or who may need them to prevent disease progression.

Dr. Kathryn C. Fitzgerald's lab focuses on understanding multiple sclerosis (MS), a complex disease affecting the nervous system. The lab investigates metabolic changes in individuals with MS to identify biomarkers that can predict disease progression and reveal new therapeutic targets. Using advanced analysis of metabolic profiles, they aim to enhance personalized approaches to MS treatment and improve outcomes for patients.

Dr. Andrew Josef Ewald's lab at Johns Hopkins University studies how cancer cells change and behave as they spread from one part of the body to another. They use cutting-edge techniques, including single-cell sequencing and machine learning, to map these changes and understand the processes driving metastasis in breast cancer. The lab aims to identify potential new targets for treatments that could stop cancer from spreading and improve patient outcomes.

Dr. Kelly Alexander Mills's lab at Johns Hopkins University focuses on understanding the role of microglia, the brain's immune cells, in Parkinson's disease. The research aims to explore how microglial activation affects cognitive and motor functions in patients, particularly in those with varying degrees of disease severity. By developing and using specialized imaging techniques, the lab seeks to correlate microglial activity with cognitive decline and other pathological biomarkers, which may lead to new treatment strategies for Parkinson's disease.

Dr. Michael I. Miller leads a research lab at Johns Hopkins University focused on understanding how Alzheimer's disease affects specific brain regions, particularly the entorhinal cortex, which deteriorates early in the disease. The lab employs advanced MRI techniques along with histological and molecular analyses to correlate structural brain changes with cognitive impairment and disease progression. This research aims to develop new MRI-based biomarkers that could aid in the early detection and treatment of Alzheimer's disease.

Hiromi Sesaki's research lab at Johns Hopkins University focuses on understanding how mitochondria, the energy-producing structures in cells, maintain their shape and function. The lab explores how mitochondrial dynamics—such as their growth, division, and fusion—are regulated and how these processes are linked to various diseases including neurodegeneration and metabolic disorders. By investigating the molecular mechanisms involved, the lab aims to uncover new treatment strategies for diseases caused by mitochondrial dysfunction.

Dr. Hilary Vernon's lab at Johns Hopkins University focuses on understanding how mitochondrial function and quality control are regulated in heart cells, particularly in relation to Barth Syndrome. This research is critical because disruptions in mitochondrial maintenance can lead to serious heart problems. By exploring the effects of a specific genetic deficiency, her lab aims to uncover the underlying mechanisms of heart disease and develop potential new therapies.

Dr. Ulrich Mueller's laboratory at Johns Hopkins University focuses on understanding the function of hair cells in the inner ear, which are critical for hearing. The lab studies specific genes linked to hearing loss and how those genes affect the development and function of these hair cells. Researchers investigate the mechanisms of signal transmission in auditory circuits and the impact of genetic mutations on hearing capability.

Dr. Daniela Cihakova's lab focuses on understanding a serious side effect of cancer treatments known as immune checkpoint inhibitor-associated myocarditis, which can lead to severe heart inflammation and even death in cancer patients. The research explores how certain immune cells in the heart contribute to this condition, particularly after heart injury. By studying these immune responses in mouse models, the lab aims to uncover mechanisms that could lead to new prevention strategies for patients undergoing cancer therapy.

Dr. Valina L. Dawson's lab focuses on understanding the mechanisms underlying neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. By studying the roles of specific proteins and metabolic changes in brain cells, the lab seeks to uncover the causes of cognitive dysfunction and develop potential therapies to protect neurons. Their research uses innovative techniques, including imaging mass spectrometry and genetic models, to explore how changes in brain metabolism affect neurodegeneration.

Dr. Jiou Wang's lab at Johns Hopkins University focuses on understanding the underlying causes of neurodegenerative diseases like ALS and frontotemporal dementia (FTD). They investigate how genetic factors, particularly a mutation in the C9orf72 gene, lead to neuronal damage. The lab employs a combination of biochemical, molecular, and genetic techniques to explore how these mutations disrupt protein and RNA functions, contributing to neurodegeneration. Ultimately, their goal is to find new avenues for treatment and intervention for these serious neurological conditions.

Dr. Shuying Sun's lab at Johns Hopkins University focuses on understanding the molecular mechanisms behind neurodegenerative diseases like ALS and Alzheimer's. They study how certain types of RNA related to genetic mutations can become toxic to nerve cells and lead to these conditions. By using advanced imaging techniques and genetic analysis, the lab aims to uncover new insights that could help develop effective treatments for these debilitating diseases.

Professor Reza Kalhor's research lab focuses on understanding how genetic changes affect brain development and lead to conditions like autism. By using advanced genomic techniques, they aim to create detailed maps of how brain cells develop from their early stages. This knowledge could help uncover the origins of developmental disorders and improve public health outcomes.

Dr. Hanseok Ko's research lab focuses on understanding how a specific protein signaling pathway in brain immune cells, called microglia, contributes to neuroinflammation and neurodegeneration in Alzheimer's disease. The lab aims to identify the molecular mechanisms involved in this process and explore potential new therapies for Alzheimer's by targeting these pathways. Through a combination of biochemical and genetic experiments, the lab seeks to uncover ways to mitigate the harmful effects associated with Alzheimer's disease and improve brain health.

Dr. Ted Dawson's lab at Johns Hopkins focuses on understanding the mechanisms of neurotoxicity related to stroke and neurodegenerative diseases. They investigate a specific form of cell death called parthanatos, particularly how the enzyme associated with it, known as PAAN/MIF, contributes to injury in neurons. The ultimate goal of the research is to develop innovative therapies to protect neurons from damage and improve outcomes for patients suffering from strokes and similar conditions.