Dr. James Salzer's lab at NYU focuses on understanding how Schwann cells, which support and insulate nerve fibers, influence the health and function of axons. By studying genetically modified mice, the lab investigates how defects in Schwann cells lead to neurodegenerative diseases, particularly focusing on the mechanisms behind conditions like Charcot-Marie-Tooth disease. The research has the potential to reveal new treatment approaches for peripheral nerve disorders that result from Schwann cell dysfunction.

Dr. Tamar Schlick's research lab at New York University focuses on using advanced computer modeling to understand how the structure of DNA and RNA impacts their function, especially in relation to cancer and viral infections like COVID-19. The lab combines insights from mathematics, engineering, and biology to develop models that explain complex biological processes, such as how chromatin (the material that makes up chromosomes) organizes in the cell and how viruses manipulate their RNA to survive. This work aims to lead to improved diagnostic and therapeutic strategies for various diseases.

Dr. Jonas Schluter's lab at NYU School of Medicine is focused on understanding how the human gut microbiome relates to health and disease, especially in cancer patients. They study how the microbiome can influence drug effectiveness and how certain microbes may compete with harmful pathogens. Using advanced data analysis techniques, including machine learning, the lab aims to uncover new ways to engineer beneficial changes in the microbiome for therapeutic purposes.

Dr. Susan Ruth Schwab's research focuses on understanding how T cells exit from sites of inflammation, which is crucial for immune responses. By exploring the role of specific lipids in guiding T cell movement, her lab aims to uncover mechanisms that could prevent T cell exhaustion and improve memory responses during chronic inflammation. They utilize a novel mouse model to manipulate gene expression in a targeted manner, enabling detailed studies of T cell behavior in real time.

Hai Shu's lab focuses on innovative statistical machine learning approaches to improve the diagnosis and prediction of Alzheimer's Disease. Their research uses multi-view data, such as brain images and genetic information, to uncover new insights and biomarkers associated with Alzheimer's. This work aims to provide better tools for early detection, which can lead to more effective treatments and improved patient outcomes.

Dr. Duncan J. Smith's lab at New York University focuses on understanding how DNA processes like replication and transcription interact and sometimes conflict with each other. They use yeast as a model to explore the behaviors of helicases—proteins that unwind DNA—and how their activities affect genome integrity, especially in relation to cancer. The lab develops novel methods to map these interactions and aims to provide insights that could help in understanding diseases related to DNA damage.

Dr. Jeremy S. Dasen's lab at New York University School of Medicine studies how neurons in the spinal cord assemble the networks necessary for controlling movement. They focus on understanding the genetic factors that shape these neurons during development, particularly the role of Hox transcription factors in creating different types of motor neurons. The lab aims to uncover the molecular mechanisms behind motor circuit formation, which could lead to therapies for spinal cord injuries and diseases.

Dr. Claude Steriade's research lab at NYU School of Medicine focuses on advancing the diagnosis and treatment of autoimmune epilepsy. By using innovative imaging techniques like TSPO-PET and MRI, the lab aims to uncover the underlying neuroinflammatory processes that contribute to the condition. The ultimate goal is to develop more effective diagnostic markers and treatment strategies for patients suffering from this complex disorder.

Dr. David L. Stokes' lab focuses on understanding how cells transport ions like potassium and zinc across their membranes. By combining advanced techniques such as cryo-electron microscopy and molecular dynamics simulations, the lab investigates the mechanisms that regulate these transport processes. This research not only provides insights into cellular ionic homeostasis but also has implications for understanding how these processes can be disrupted in diseases.

Dr. Erik Sulman's research lab focuses on understanding and overcoming radiation resistance in glioblastoma, a severe type of brain cancer. By exploring how glioblastoma stem-like cells change states, the lab aims to find new ways to make these cancer cells more sensitive to radiation therapy. The research combines advanced genetic techniques with clinical data to develop better treatment strategies for patients suffering from this challenging disease.

Dr. Michelle Krogsgaard's lab focuses on enhancing the effectiveness of T cell-based immunotherapies for cancer treatment. By studying the signaling pathways of T cell receptors, the lab aims to improve the ability of T cells to recognize and kill tumor cells without compromising their specificity. This research holds promise for developing better strategies in cancer immunotherapy, particularly for melanoma.

Dr. Henrieta Scholtzova's lab at NYU School of Medicine is focused on understanding how the immune system can be harnessed to tackle Alzheimer's disease, particularly through a unique approach using the TLR9 pathway. The lab uses squirrel monkeys, which develop age-related amyloid conditions similar to humans, to test new therapies aimed at improving cognitive function and preventing complications that often arise with current treatments. By integrating various biomarker data and advanced imaging techniques, they aim to better understand and treat cerebral amyloid angiopathy, a common risk factor for cognitive decline in Alzheimer's patients.

Claude Desplan's lab at New York University studies two main areas: the unique aging process in ants and the development of neural diversity in the fruit fly Drosophila. The lab investigates how environmental factors influence aging and longevity in ants, particularly focusing on the reproductive role of certain workers that can dramatically extend their lifespan. Additionally, they explore how different neurons are formed in the fly brain, looking at the various mechanisms that contribute to neural diversity and circuit formation. Through these studies, the lab aims to uncover fundamental principles of biology that may have implications for understanding aging and neural development in other animals.

Esteban Mazzoni's lab at NYU School of Medicine focuses on understanding how Hox genes, which are essential for the body's development, maintain their positional identity through epigenetic memory. The lab investigates how different signaling factors interact with chromatin to properly activate or repress these genes during cell differentiation. This research has implications for understanding developmental processes and diseases such as cancer.

Dr. Xiangpeng Kong's lab is focused on developing innovative vaccines against HIV/AIDS, particularly targeting a crucial site on the HIV-1 virus that can elicit strong immune responses. They utilize a unique approach by combining HIV fusion peptide immunogens with cholera toxin subunit B to create potent vaccine candidates. The lab aims to enhance the effectiveness and coverage of antibody responses that could lead to a successful vaccine against HIV.

Dr. Mariana Lazar's lab at NYU School of Medicine focuses on understanding how iron deficits may contribute to cognitive and psychological symptoms in individuals with Psychotic Spectrum Disorders. By using advanced imaging techniques, the lab seeks to explore the relationship between brain iron levels and mental health outcomes, ultimately aiming to develop new treatment strategies for these conditions.

Thales Papagiannakopoulos's lab focuses on understanding and treating aggressive forms of lung cancer driven by KRAS mutations, particularly those with mutations in the KEAP1 gene. They explore novel therapeutic strategies that target specific metabolic vulnerabilities and immune evasion mechanisms in these tumors, aiming to improve treatment options for patients with KRAS mutant lung cancer.

Iannis Aifantis' lab at NYU focuses on understanding the mechanisms of acute myeloid leukemia (AML) and other blood cancers. The research explores how RNA-binding proteins affect cell differentiation and how inflammation impacts the immune response in leukemia. By using advanced techniques like CRISPR, the lab aims to identify new therapeutic targets and improve treatment outcomes for leukemia patients.

Dr. Matija Snuderl's lab at NYU School of Medicine focuses on understanding medulloblastoma, the most common malignant brain tumor in children. The team investigates how certain biological processes can be harnessed to induce maturation in these tumors, making them less aggressive and more treatable. Through advanced techniques in genetics and drug delivery, the lab aims to develop new therapies that are less toxic than current treatments.

Dr. Dan Littman's lab at NYU School of Medicine focuses on how the gut microbiome influences the effectiveness of immunotherapy in lung cancer. By studying specific bacterial species and their products, the lab aims to uncover mechanisms that enhance immune responses against tumors, potentially leading to better treatment outcomes for patients. This research could help identify which patients may benefit most from immunotherapy and reduce harmful side effects.