Dr. Elisabeth Breese Marsh's lab at Johns Hopkins University focuses on understanding and addressing vascular cognitive impairment in patients who have experienced minor strokes. The research aims to identify noninvasive digital biomarkers to predict cognitive decline, leveraging advanced neuroimaging techniques like magnetoencephalography (MEG) and electroencephalography (EEG) combined with deep learning methods. Ultimately, their goal is to develop tools that can help identify patients at risk for cognitive impairment after stroke, leading to timely interventions that could improve patient outcomes.

Dr. Sotiris Masmanidis' lab at UCLA focuses on understanding how the brain's timing mechanisms are intertwined with the reward learning process, specifically through the study of dopamine neurons in the midbrain. The lab employs a combination of experimental techniques and computational modeling to investigate how these neural circuits learn to predict when rewards are expected, which is important for behaviors like learning and decision-making. This research could shed light on fundamental processes that, when disrupted, can lead to issues like addiction.

Professor Joseph R. Mazzulli's lab at Northwestern University focuses on understanding how the accumulation of a-synuclein, a protein involved in neurodegenerative diseases like Parkinson's disease and dementia with Lewy bodies, affects cellular functions. The lab investigates how a-synuclein aggregates disrupt lysosomal function and protein trafficking, aiming to find new treatments that restore these cellular processes. By using advanced cellular models and small molecules, the research aims to decipher the underlying mechanisms of neurodegeneration and enhance lysosomal biogenesis to alleviate disease symptoms.

Dr. James Mccallum Noble's lab is focused on understanding the links between oral health, specifically periodontal infections, and Alzheimer's Disease. They are investigating how periodontitis may contribute to cognitive impairment and dementia in older adults. By studying a diverse group of elderly participants over time, they aim to uncover potential mechanisms connecting these two health issues and provide insights for prevention and early intervention strategies.

Dr. Louise D. Mccullough's lab focuses on understanding how sex and age affect the body's response to neurological conditions like stroke and COVID-19. The research aims to uncover biological differences that lead to varying outcomes in men and women, especially regarding inflammation and recovery. By investigating these differences, the lab hopes to develop targeted therapies to improve treatment for all patients affected by neurological diseases.

Dr. Eric McDade's lab at Washington University focuses on Alzheimer's disease, specifically testing if early intervention can prevent the onset of the disease in individuals with a genetic predisposition. The lab conducts clinical trials aimed at stopping amyloid plaque formation, which is associated with Alzheimer's pathology, by using innovative anti-amyloid therapies. Their research seeks to radically change how Alzheimer's is approached, making it possible to intervene before symptoms appear.

Dr. Marisa McGinley's research lab focuses on improving the care and quality of life for patients with multiple sclerosis (MS) by exploring the effectiveness of telehealth compared to traditional in-clinic visits. The lab is conducting a study to evaluate the clinical and economic outcomes of telehealth care for newly diagnosed MS patients, with aims to enhance accessibility and reduce costs associated with MS treatment.

Dr. Dana Mctigue's lab at Ohio State University focuses on understanding how spinal cord injuries (SCI) impact liver health and metabolic functions. The research aims to uncover the mechanisms behind liver disease, specifically non-alcoholic fatty liver disease, in individuals with SCI and to find ways to improve their overall metabolic health. By studying the interactions between the nervous system and liver, the lab aims to identify potential therapies that could enhance recovery and reduce complications in spinal cord injury patients.

Dr. Christina S. Meade's lab focuses on understanding how chronic stress and substance use, particularly stimulants, impact people living with HIV. By exploring the connections between psychological stress, neuroimmune function, and mental health disorders like depression, the lab aims to develop interventions that can improve the lives of those affected by these issues. The research also looks at broader community factors that influence health outcomes among populations at risk for or living with HIV.

Dr. Cristina Alberini's lab focuses on understanding how memories are formed and maintained at the molecular level. They study the role of certain genes, particularly insulin-like growth factor 2 (IGF-2), in strengthening long-term memories. By exploring the mechanisms of memory consolidation, the lab aims to develop strategies to treat cognitive impairments associated with disorders like autism and Alzheimer's disease.

Dr. Eric Klann's lab at New York University focuses on understanding how protein synthesis affects memory and language in brain disorders. By studying specific brain regions in mice, they aim to uncover the processes behind memory storage, retrieval, and loss. They are also investigating how abnormalities in protein translation contribute to diseases like Alzheimer's and fragile X syndrome, with hopes of finding new treatment targets.

Dr. Anli A Liu's research lab at NYU School of Medicine focuses on understanding how the brain organizes and recalls memories, particularly through the interactions between the hippocampus and the neocortex. By studying brain activity in epilepsy patients while they watch films and engage in visual exploration, the lab aims to uncover how memories are formed and segmented into distinct events. This research has important implications for improving diagnosis and treatment of memory disorders.

The lab led by Dr. Jean-Leon Thomas at Yale University focuses on understanding how specialized blood vessels in the brain called meningeal lymphatic vessels influence the immune system during early development. The research emphasizes the relationship between these vessels and neuroimmune communication, particularly in relation to pediatric brain tumors like medulloblastoma. By utilizing advanced imaging techniques and genetic mouse models, the lab aims to uncover how these vessels can enhance T cell education and potentially improve treatments for childhood cancers.

Dr. Teresa A Milner's lab focuses on understanding how menopause affects blood pressure and the brain's mechanisms behind this change using mouse models. They specifically look at hormonal changes associated with menopause and how they influence hypertension, particularly through brain signaling pathways. By exploring the roles of estrogen receptors and synaptic plasticity in the hypothalamus, the lab aims to uncover potential new therapies to manage hypertension in postmenopausal women.

Dr. Huxing Cui's lab at the University of Iowa focuses on understanding how certain brain cells in the hypothalamus control metabolism differently between males and females. They study a specific signaling pathway that is linked to obesity, especially in women. The lab uses advanced techniques to explore how changes in neuron function can influence energy balance, with the ultimate goal of helping to develop better obesity treatments.

Dr. Stacie Demel's lab focuses on understanding how metabolic changes in the body relate to recovery from a type of stroke called intracerebral hemorrhage. Specifically, they study how these metabolic responses differ by race and ethnicity, especially among Black and Hispanic populations who experience higher rates of stroke. Through analyzing blood samples and other data, the lab aims to identify potential new treatments that can help improve recovery outcomes for these patients.

Dr. Kathryn C. Fitzgerald's lab focuses on understanding multiple sclerosis (MS), a complex disease affecting the nervous system. The lab investigates metabolic changes in individuals with MS to identify biomarkers that can predict disease progression and reveal new therapeutic targets. Using advanced analysis of metabolic profiles, they aim to enhance personalized approaches to MS treatment and improve outcomes for patients.

Dr. Kelly Alexander Mills's lab at Johns Hopkins University focuses on understanding the role of microglia, the brain's immune cells, in Parkinson's disease. The research aims to explore how microglial activation affects cognitive and motor functions in patients, particularly in those with varying degrees of disease severity. By developing and using specialized imaging techniques, the lab seeks to correlate microglial activity with cognitive decline and other pathological biomarkers, which may lead to new treatment strategies for Parkinson's disease.

Dr. Gab Seok Kim's research lab focuses on understanding how microglia, the brain's immune cells, respond to strokes, particularly in older adults. The lab investigates a specific gene called Ifi27l2a that may heighten inflammation in the brain after a stroke, examining its role in both worsening brain injury and potential recovery. Through various experimental approaches, they aim to discover how manipulating this gene could lead to better treatment strategies for stroke and related neurodegenerative diseases.

Rebecca Erwin Wells' lab focuses on improving the lives of people living with migraine, a condition affecting millions of Americans. The lab is developing and evaluating online, non-drug interventions that could offer effective relief from migraine symptoms without the use of opioids. By leveraging electronic health solutions, the lab aims to create scalable treatments that are accessible to a wide audience, addressing the significant health burden caused by migraines.