Dr. Angela Filous's lab at Ohio State University focuses on understanding how infections, particularly pneumonia, impact recovery after spinal cord injuries. They explore the mechanisms behind impaired recovery and aim to find ways to protect spinal cord function in patients. The lab uses various experimental models to investigate the cellular and molecular interactions involved in injury and repair processes following infection.

Dr. Dana Mctigue's lab at Ohio State University focuses on understanding how spinal cord injuries (SCI) impact liver health and metabolic functions. The research aims to uncover the mechanisms behind liver disease, specifically non-alcoholic fatty liver disease, in individuals with SCI and to find ways to improve their overall metabolic health. By studying the interactions between the nervous system and liver, the lab aims to identify potential therapies that could enhance recovery and reduce complications in spinal cord injury patients.

Dr. Karl H. Obrietan's lab focuses on understanding how circadian rhythms affect brain functions, particularly in areas related to mood, memory, and decision-making. They investigate how the brain's internal clock interacts with different brain circuits and how disruptions in this timing can lead to neurological disorders. By using innovative techniques, including advanced imaging and genetic models, the lab aims to uncover the biological mechanisms behind these processes and their implications for treatment.

Dr. Benjamin Segal's lab focuses on understanding and treating progressive forms of multiple sclerosis (PMS) and promoting nerve regeneration in the optic nerve. His research investigates the role of specific immune cells in driving neuroinflammation and potential therapies to enhance recovery from nerve injuries. This work aims to reduce disability in older adults suffering from PMS and to develop new treatments for individuals facing vision loss due to optic nerve damage.

Dr. Ilaria Palmisano's lab at Ohio State University focuses on understanding how the structure of DNA, specifically its 3D organization, affects the ability of nerves to regenerate after injuries. This research is crucial because nerve injuries can lead to long-lasting health issues and disabilities. By manipulating the molecular mechanisms involved in gene expression, the lab aims to develop new therapeutic strategies to enhance nerve repair and recovery.

Dr. Erica R. Glasper's research lab at Ohio State University focuses on understanding how social relationships impact mental and physical health. They study the effects of losing social connections, such as through loneliness, and explore the biological processes involved, particularly looking at inflammation and metabolic changes in the brain. By using California mice as a model, the lab aims to uncover potential interventions to improve health outcomes for individuals suffering from social isolation.

Dr. Giles Plant's research focuses on finding innovative ways to repair cervical spinal cord injuries using human neurons derived from induced pluripotent stem cells (iPSCs). His lab develops and tests transplantation strategies where these neurons are integrated into injured spinal cords, aiming to restore motor function and improve the quality of life for patients. By studying how these transplanted neurons form connections and integrate into existing neural circuits, the lab seeks to make significant advances in regenerative therapies for spinal injuries.

The research lab of Dr. Hongjun Fu at Ohio State University focuses on understanding the mechanisms behind neuronal vulnerability in Alzheimer's disease, particularly regarding a protein called WFS1. They explore how deficiencies in this protein contribute to the accumulation of toxic tau proteins in neurons, leading to cognitive decline. By studying the pathways involved, they aim to uncover potential therapeutic targets for treating and preventing neurodegenerative diseases.

Dr. Lihua Ye’s research lab at Ohio State University focuses on how microorganisms in the gut can influence brain function and contribute to anxiety and disorders such as irritable bowel syndrome (IBS). The lab explores the role of specific gut bacteria and their interactions with gut cells that produce serotonin, investigating the cellular and signaling pathways involved. By understanding these connections, Dr. Ye aims to identify new treatments that target gut-brain communication and improve health outcomes for individuals with neurological and gastrointestinal disorders.