Dr. Cory Abate-Shen's research lab focuses on understanding the mechanisms of prostate cancer and bladder cancer progression. The lab employs advanced models, including genetically-engineered mice and patient-derived organoids, to investigate how specific genes and mitochondrial functions affect cancer development and metastasis. These studies aim to identify potential therapeutic targets for treatment.

Dr. Dritan Agalliu's lab at Columbia University focuses on understanding traumatic brain injury (TBI) and its effects on the brain's blood-barrier system. Using advanced human cell models, particularly stem cells, the lab investigates how immune responses and blood components impact brain function after injury. They aim to develop innovative models that can help identify new biomarkers for TBI and test potential treatments to mitigate its effects.

Dr. Robbie M Parks' lab focuses on understanding how air pollution, particularly fine particulate matter (PM2.5), impacts the development of Lewy body dementia, a serious neurodegenerative disease. They combine large-scale data analysis with animal studies to identify which specific components of air pollution contribute to the disease's pathology. The lab's ultimate goal is to inform public health policies and therapeutic strategies to mitigate the effects of these environmental factors on aging populations.

Dr. Junhao Wen's lab at Columbia University focuses on understanding Alzheimer's Disease and aging through innovative multi-organ research. By leveraging large-scale biomedical data and advanced artificial intelligence techniques, the lab aims to develop a personalized chart that assesses individual susceptibility to these conditions. This research could lead to better diagnosis and treatment strategies, ultimately enhancing patient care.

Dr. Richard P Mayeux's lab at Columbia University focuses on studying blood-based biomarkers for Alzheimer's Disease, particularly in diverse populations. They investigate how these biomarkers can help improve diagnosis and understanding of the disease, using innovative techniques and community-based studies. Their work aims to identify genetic risk factors and how various elements like age, sex, and race impact Alzheimer's diagnosis.

Dr. Zhonghua Liu's lab focuses on developing advanced statistical methods to analyze complex genetic and multi-omics data, particularly in relation to Alzheimer's disease. The lab aims to identify biomarkers that can help diagnose the disease early and inform personalized treatment strategies. By leveraging innovative computational algorithms, the team works on understanding the biological processes behind neurodegeneration to improve health outcomes, especially in diverse populations.

Dr. Gao Wang's lab focuses on understanding the genetic and molecular basis of Alzheimer's Disease (AD) by using advanced computational methods and multi-omics data. They study how genetic variations affect RNA modifications and other molecular traits in brain cells, particularly in diverse populations such as African Americans and Hispanics. The ultimate goal is to identify specific genes and processes that contribute to AD, which may pave the way for new therapeutic strategies.

Dr. Tal Nuriel's lab at Columbia University focuses on understanding how long-term infections with herpes simplex virus (HSV-1) may contribute to the development of Alzheimer's disease, particularly in individuals with a genetic predisposition (APOE4 allele). The research aims to reveal the complex interactions between viral infection and brain function, which may lead to new treatments for preventing or slowing Alzheimer's disease in at-risk populations.

Dr. Andrew Teich's lab focuses on understanding how Alzheimer's Disease affects brain structure and function, particularly in elderly patients with normal pressure hydrocephalus. By examining brain tissue and cerebrospinal fluid from surgical patients, the lab investigates the role of immune responses in the brain and how they relate to cognitive decline. This research aims to identify biomarkers that could help predict outcomes in Alzheimer's patients, thereby improving clinical care.

Dr. Linda Valeri's lab at Columbia University focuses on using advanced statistical techniques to understand the causes of Alzheimer's Disease and related disorders (ADRD). The research aims to develop new methods for analyzing how various environmental factors and health conditions affect the risk of ADRD over time. By utilizing large cohort studies and sophisticated Bayesian machine learning approaches, the lab seeks to provide insights that can inform prevention strategies and health policies.

Dr. Minah Kim's lab focuses on understanding how the Angiopoietin-2/Tie2 signaling pathway affects liver metastasis in pancreatic neuroendocrine tumors (PanNET). By investigating the mechanisms of tumor growth and immune evasion, the lab aims to improve treatment strategies for patients suffering from this aggressive cancer. Ultimately, the research seeks to identify potential biomarkers that could help guide clinical decisions for better management of metastatic disease.

Dr. Nicholas Arpaia's lab at Columbia University focuses on innovative approaches to cancer immunotherapy, particularly for colorectal cancer and other challenging tumors. They study how engineered probiotics can enhance the immune system's response to tumors by delivering targeted therapies and vaccines directly to the site of disease. The lab aims to improve therapeutic outcomes by modulating bacterial behavior in the body and understanding how the gut microbiome influences cancer progression and immune activity.

Dr. Uttiya Basu's lab focuses on understanding how B cells, which are crucial for our immune system, diversify antibodies to fight infections. The lab is exploring the role of non-coding RNAs and specific protein complexes that help organize and modify the DNA in B cells during their development. Understanding these processes is important because mistakes in them can lead to immune deficiencies and cancers.

The lab of Dr. Andres Bendesky at Columbia University focuses on understanding the biological mechanisms that influence parental behavior, particularly in relation to the neurosteroid allopregnanediol. By studying different species of mice, the research aims to uncover how hormones affect the motivation for parental care, which is crucial for healthy child development. The lab's work has implications for understanding postpartum depression and child neglect.

Dr. Marla J Hamberger's lab focuses on improving language assessment tools for Spanish speakers undergoing evaluations for epilepsy and other neurological conditions. Currently, many of the existing tests are only available in English, leading to disparities in care for Spanish-speaking patients. By developing and validating Spanish language tests, the lab aims to ensure that bilingual patients receive the same quality of care as their English-speaking counterparts, ultimately enhancing diagnostic accuracy and surgical outcomes.

Dr. Elizabeth M Bradshaw's lab at Columbia University focuses on understanding the link between the immune system and Alzheimer's disease (AD). They investigate how genetic factors influence the immune response to HSV-1, a virus that may play a role in AD progression. By integrating genetics, immunology, and computational biology, the lab aims to uncover the mechanisms by which HSV-1 interacts with genetic predispositions to AD and affects microglial function.

Dr. Kevin L. Gardner's lab focuses on understanding breast cancer, particularly in women of African ancestry and those in the African diaspora, who face higher mortality rates from this disease. The lab investigates a protein called Kaiso, exploring its potential as a biomarker for predicting breast cancer outcomes and how it interacts with the tumor microenvironment. By combining advanced genetic analysis techniques, the research aims to develop better prognostic models and therapeutic strategies for breast cancer.

The research lab led by Dr. Andrew Robert Marks focuses on understanding the muscle symptoms that can arise from statin medications, which are commonly used to treat cardiovascular diseases. They investigate the biological mechanisms behind these symptoms, particularly how alterations in specific calcium channels in muscle tissue may contribute to muscle weakness. The lab also explores potential therapeutic options to reduce these side effects and enhance patient adherence to statin therapy.

Dr. Ke Cheng's lab focuses on innovative therapies to repair heart damage caused by diseases like myocardial infarction. They investigate the use of long noncoding RNAs and exosomes derived from stem cells to enhance cardiac repair, as well as using novel delivery methods to ensure these therapies effectively target injured heart tissue. Their work blends biology, engineering, and translational medicine to optimize treatments that could potentially save lives.

Iva S. Greenwald's lab at Columbia University focuses on understanding how cells communicate and decide their roles during development using the model organism C. elegans, a tiny roundworm. By investigating the Notch signaling pathway and its interactions with other key signaling systems, the lab aims to uncover fundamental mechanisms that can impact human health, particularly in relation to cancer and congenital disorders. The research combines traditional genetic techniques with modern genome engineering tools, enabling detailed study of cellular processes and signaling dynamics.