Dr. Ari Rosenberg's lab at the University of Wisconsin-Madison focuses on understanding how primates perceive and interact with the three-dimensional (3D) world. By studying the neural circuits in the brain associated with visual processing and eye movements, the lab aims to uncover the underpinnings of 3D perception and its implications for both normal cognition and neurodevelopmental disorders. The research combines behavioral experiments and advanced techniques to provide insights relevant to both basic science and potential therapeutic applications.

Dr. Kevin Michael Johnson's lab at the University of Wisconsin-Madison focuses on developing advanced MRI techniques to better understand complex health issues in pediatric patients and Alzheimer's disease. The lab's innovative approaches aim to combine multiple imaging techniques into a single, efficient MRI scan, improving the diagnosis and treatment for cardiopulmonary diseases in children and helping to explore the connections between cardiovascular health and Alzheimer's disease progression. Through their work, they seek to revolutionize clinical practice with state-of-the-art imaging methods that capture vital physiological functions.

Dr. Lingjun Li's lab focuses on advancing our understanding and diagnosis of Alzheimer's disease (AD) through innovative technologies. The research aims to discover and validate biomarkers associated with AD using advanced mass spectrometry techniques and molecular mapping strategies. By doing this, the lab hopes to shed light on the progression of AD and improve early diagnostic capabilities for this devastating disease.

Dr. Ulland's lab focuses on understanding how a substance called beta-hydroxybutyrate (BHB) can impact the progression of Alzheimer's disease. They explore how BHB may alter brain pathology and cognition through its effects on the microbiome and immune response. This research is aimed at uncovering new therapeutic strategies to help combat Alzheimer's disease, which affects many older adults.

Dr. Stephen Ferrigno's lab focuses on understanding how children and monkeys develop their ability to estimate numbers using the Approximate Number System. This system is crucial for early math skills, and the lab combines behavioral studies, genetic analysis, and computational modeling to explore factors influencing its development. The research aims to improve educational practices and early diagnosis of math-related learning disabilities by revealing how genetics, experience, and neural maturation play roles in this developmental process.

Dr. Lawrence M. Berger's lab at the University of Wisconsin-Madison focuses on understanding how economic and social factors impact family wellbeing across generations. Their research involves collecting and analyzing data on families, specifically looking at parenting, child development, and the effects of debt on health and economic security. The lab aims to inform public health and social policies by providing insights into how inequalities are transmitted through families.

Dr. Craig W. Berridge's research lab at the University of Wisconsin-Madison focuses on understanding how the prefrontal cortex (PFC) impacts goal-directed behavior. The lab explores how corticotropin-releasing factor (CRF) neurons in the PFC affect cognitive processes like memory and attention, particularly in relation to behavioral disorders. By studying the neural mechanisms involved, the lab aims to develop better treatments for cognitive dysfunctions linked to the PFC.

Dr. Feyza Engin's lab focuses on understanding how stress affects insulin-producing beta cells in Type 1 diabetes (T1D). They explore the different responses beta cells exhibit under stress, which can either lead to disease progression or help protect against it. By studying these responses, the lab aims to uncover potential therapeutic targets for preserving healthy insulin production in diabetic patients.

Dr. Anita Bhattacharyya's lab at the University of Wisconsin-Madison focuses on understanding Down syndrome, a genetic condition that often leads to intellectual disabilities. The lab investigates how trisomy 21 affects brain development, specifically looking at neuronal formation and synaptic connections. By using innovative stem cell models, they aim to uncover the molecular mechanisms behind cognitive impairments in Down syndrome, which could inform future therapeutic strategies.

Dr. Michael D. Sheets' lab at the University of Wisconsin-Madison studies how specific proteins control gene expression during development, focusing on a protein called Bicaudal-C. This protein is crucial for making cell fate decisions that guide the normal development of vertebrates, including humans. The lab employs innovative techniques to unravel Bicaudal-C's role in regulating mRNA translation, which may lead to better understanding of diseases linked to cell dysfunction.

Dr. Sabine Pellett's lab at the University of Wisconsin-Madison focuses on understanding Botulinum Neurotoxins (BoNTs), which are potent toxins capable of causing severe disease. The lab investigates how these toxins work at a molecular level, especially regarding their duration and potency, which are crucial for both therapeutic applications and understanding their risks as potential bioweapons. Through innovative experimental approaches, the team aims to develop better treatments and countermeasures against botulism and related disorders.

Dr. Amy Fowler's lab at the University of Wisconsin-Madison focuses on improving how breast cancer patients are treated by developing advanced imaging techniques to help predict how well they will respond to a specific type of hormone therapy. The research aims to create more personalized treatment plans by using non-invasive imaging methods that can detect changes in tumors after treatment begins. This innovative approach is expected to lead to better outcomes for patients with hormone receptor positive breast cancer.

Dr. Samuel E. Butcher's lab at the University of Wisconsin-Madison focuses on understanding how RNA-protein complexes regulate gene expression and their implications for genetic disorders. Using a variety of biophysical methods, the research explores the structural dynamics of essential RNA components like the spliceosome and the role of newly discovered RNA types involved in gene silencing. This work aims to uncover the molecular mechanisms underlying these interactions and their connection to diseases such as Alzheimer's and ALS.

Dr. Junsu Kang's lab at the University of Wisconsin-Madison focuses on understanding how zebrafish can repair their hearts after injury. By studying the genetic and cellular mechanisms involved in this regeneration process, the lab aims to uncover potential strategies for healing hearts in humans, particularly after damage from disease or trauma. This innovative research could lead to groundbreaking treatments for heart diseases, which remain a leading cause of death worldwide.

Dr. Anoop Mayampurath's research lab is focused on improving healthcare outcomes for hospitalized children, particularly by predicting cardiopulmonary deterioration. The lab is developing a new clinical decision support tool that uses machine learning to analyze electronic health records and provide real-time insights for healthcare providers. This tool aims to enable timely interventions, ultimately enhancing the quality of care for pediatric patients at risk.

Dr. Sean P Palecek's research lab focuses on improving the manufacturing processes for human pluripotent stem cell-derived cardiomyocytes, which are essential for developing effective cell therapies for heart disease and other conditions. By using advanced techniques like single-cell profiling, they aim to identify and correct failures in the differentiation process, making it more reliable and cost-effective. The lab works with both 2D and 3D bioreactor systems to enhance the scalability and reproducibility of these important cells.

Dr. Andrew L. Wentland's lab focuses on improving CT urography, a technique used to diagnose causes of blood in urine. They have developed a novel synthetic imaging method that enhances the accuracy of kidney imaging while significantly reducing the radiation dose and the time required for the examination. The lab combines advanced image processing with deep learning to create images that help in diagnosing kidney conditions more safely and efficiently.

Dr. Joan S Jorgensen's lab focuses on understanding key mechanisms that influence female fertility, particularly how specific proteins impact the development of ovarian follicles and the implantation of embryos. Through their research, the lab investigates the critical roles of Iroquois homeobox proteins in these processes, aiming to contribute to better understanding of fertility issues such as premature ovarian reserve loss and implantation failures. Ultimately, this research seeks to uncover strategies that might improve health outcomes related to female reproductive success.

Dr. Edwin R. Chapman's lab at the University of Wisconsin-Madison studies the molecular mechanics of membrane fusion in neurons, focusing on the release of neurotransmitters. The team utilizes innovative techniques to analyze the dynamics and structure of fusion pores, which are crucial for synaptic transmission. Their research aims to answer key questions about how neurons communicate and the potential implications for treating mental disorders.

Dr. Guang-Hong Chen's research lab focuses on advancing imaging technologies for medical applications, particularly in computed tomography (CT). The lab aims to create new imaging systems that improve diagnostic accuracy while reducing patient exposure to radiation. Key projects include developing a next-generation cone beam CT system that incorporates photon counting technology and introducing a one-stop-shop CT imaging method for abdominal examinations, which enhances the diagnostic process by simplifying image acquisition and analysis.