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Steven Alan Goldman — Dr. Steven Alan Goldman's lab at the University of Rochester focuses on understanding how HIV affects the human brain, particularly how it leads to cognitive disorders. They employ unique mouse models that incorporate human brain cells to better study the effects of this virus, especially in conjunction with factors like drug addiction. The lab aims to uncover how HIV alters brain cell functions and contributes to cognitive problems in infected individuals.
John J Foxe — Dr. John J. Foxe's research lab at the University of Rochester focuses on understanding how the brain develops in children and adolescents. His team is part of the ABCD Study, the largest long-term investigation of brain health and development in the U.S., tracking over 11,000 children as they grow. The lab examines various factors, including mental health, substance use, and social experiences, to see how they influence brain development and cognitive abilities over time.
Vera Gorbunova — The research lab led by Dr. Vera Gorbunova at the University of Rochester focuses on understanding the aging process and strategies to maintain genomic stability in cells. They investigate how certain genes, particularly Sirtuin 6, influence lifespan and epigenetic rejuvenation, and use comparative genomics to explore longevity mechanisms in various animal species. The goal is to apply these insights to prevent age-related diseases such as Alzheimer's.
Lynne E Maquat — Dr. Lynne Maquat's lab at the University of Rochester explores how cells manage their RNA molecules, particularly focusing on a process called nonsense-mediated mRNA decay (NMD). This process helps eliminate faulty RNA that could result from genetic errors and is crucial for maintaining healthy gene expression. The lab's research aims to understand how disruptions in these RNA processes could relate to diseases like fragile X syndrome and various muscle disorders.
David H. Mathews — The Mathews lab at the University of Rochester focuses on understanding RNA molecules, which play crucial roles in biology and can be used in pharmaceuticals. They work on developing software and algorithms to predict RNA structures, which are vital for their functions. By studying these structures, the lab aims to contribute to our understanding of disease mechanisms and the development of RNA-based drugs.
Andrei Seluanov — Dr. Andrei Seluanov's lab at the University of Rochester focuses on understanding how the stability of the epigenome is regulated during aging, particularly through the action of the SIRT6 protein. The lab investigates the molecular mechanisms that underlie age-related declines in cell and organ function, leveraging techniques like mass spectrometry and genetic models to explore how SIRT6 influences DNA repair and longevity. Their work aims to discover new treatments for age-related diseases by revealing insights into the aging process.
Robert T Dirksen — Dr. Robert Dirksen's lab focuses on understanding tubular aggregate myopathy (TAM), a genetic muscle disease that affects strength and endurance. The team utilizes specially designed mouse models to explore the underlying mechanisms of this disease and to test potential treatments. Their work aims to provide new insights that could ultimately lead to effective therapies for people suffering from TAM.
Eric J Wagner — Dr. Eric Wagner's lab at the University of Rochester focuses on understanding how the Integrator Complex, a group of proteins involved in gene regulation, affects the function of neurons. By studying how specific proteins interact within this complex, the lab aims to uncover the molecular mechanisms that regulate neuronal development and function, particularly in the context of neurological disorders. The research holds promise for insights that could improve health outcomes and tackle brain-related diseases.
Giovanni Schifitto — Dr. Giovanni Schifitto's lab focuses on understanding how conditions like HIV and SARS-CoV-2 affect the brain, particularly how they influence small blood vessels and cognitive health. The research explores the role of immune cells and specific proteins in causing or exacerbating cognitive decline and vascular diseases. By studying these mechanisms, the lab aims to identify potential interventions to protect brain health in affected populations.