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Eric M Morrow — Dr. Eric Morrow's lab at Brown University investigates the biological mechanisms behind neurodevelopmental and neurodegenerative disorders. The research focuses on genetic factors, particularly copy number variations (CNVs), that increase the risk of conditions like autism. By studying animal models and human stem cells, the lab seeks to understand how these genetic changes affect brain development and neuronal health, with the goal of developing new therapeutic strategies.
Sean Edward Lawler — Dr. Sean Edward Lawler's lab at Brown University focuses on understanding how cytomegalovirus (CMV) influences glioblastoma, a type of aggressive brain cancer. By using a special mouse model where the virus is present, the lab aims to uncover the interactions between CMV and tumor growth, which could lead to new treatments for patients. The research highlights the potential of CMV as a therapeutic target and seeks to improve therapy effectiveness in glioblastoma patients.
Stephen L Helfand — Dr. Stephen L. Helfand's lab at Brown University focuses on understanding a rare genetic disorder resulting in severe epilepsy caused by mutations in the SLC13A5 gene. The lab utilizes advanced models, including fruit flies and mice, to explore how these mutations disrupt brain functions and develop potential treatments. Their research is crucial for linking genetics to the observed symptoms in patients, paving the way for new therapeutic strategies.
David Badre — David Badre's lab at Brown University studies how our brains manage cognitive control to help us make flexible decisions based on our goals. They focus on the prefrontal cortex, the brain area responsible for maintaining information needed to choose appropriate actions in different contexts. By exploring how information is organized and represented in the brain, the lab aims to address fundamental questions about behavior and might help develop better treatments for conditions that affect cognitive control.
Nancy P Barnett — Dr. Nancy P Barnett's lab at Brown University focuses on understanding how young adults can help each other in situations involving risky alcohol use. The research investigates the circumstances that encourage bystanders to step in and assist when they witness hazardous drinking behaviors among their peers. By studying these dynamics, the lab aims to develop effective interventions that reduce alcohol-related harm in the young adult community.
Amanda M Jamieson — Dr. Amanda Jamieson's lab at Brown University researches how the immune system responds to severe respiratory infections like influenza and bacterial pneumonia. They focus on a specific protein called Caspase-8, which helps regulate cell death in immune cells called macrophages. By studying these processes, the lab aims to find ways to improve treatments for infections that cause high rates of illness and death.
Sanghyun Lee — Dr. Sanghyun Lee's lab at Brown University focuses on understanding how viruses evade the immune responses of intestinal epithelial cells during infections. The research involves studying specific viral proteins that interact with cellular receptors to suppress immune signaling pathways. The lab aims to uncover the mechanisms behind these interactions to better understand enteric viral infections and potential therapeutic targets.
Gary M Wessel — Gary Wessel's lab at Brown University focuses on understanding how primordial germ cells are formed and regenerated during early development in animals like sea urchins and sea stars. Unlike mammals, these unique organisms allow the lab to study germline biology with advanced techniques that reveal insights into sexual reproduction and regeneration. The research aims to decode the mechanisms behind germ cell formation and explore ways these processes can be innovatively manipulated in the lab.
Lalit K Beura — Dr. Lalit K Beura's lab at Brown University focuses on understanding how specific immune cells called CD8 T lymphocytes protect the female reproductive tract from viral infections. By investigating how these cells develop and maintain their protective functions, the lab aims to improve strategies for vaccine development against viral diseases affecting this important area of the body. The research combines advanced techniques like single-cell RNA sequencing and in vitro organoid systems to explore the complex biology of immune responses.