Dr. Tobias Meyer’s lab at Weill Cornell Medical College studies how mammalian cells make decisions to move and grow, which are important for both healing and cancer development. By using advanced techniques like single-cell analysis and microscopy, the lab aims to uncover the molecular signals and interactions that guide these processes. Their findings could lead to new approaches in treating cancer and improving tissue regeneration.

Dr. Jessica K Tyler's lab at Weill Medical College focuses on understanding how certain biological processes can extend the lifespan of cells. Using yeast as a model organism, the lab investigates how autophagy—an essential process for cellular maintenance—contributes to the effects of various anti-aging interventions. Their research combines genetic manipulations and dietary interventions to reveal insights into the molecular mechanisms behind aging, which could have implications for improving health in humans.

Dr. Ethel Cesarman's lab focuses on understanding how the Epstein-Barr virus (EBV) interacts with B cells, particularly in the context of cancers associated with HIV infection. By exploring how the virus affects B cell biology and the mechanisms that control viral protein expression, the lab aims to find new therapeutic approaches for lymphomas. This research is crucial, as people living with HIV are at significantly higher risk for developing certain types of B cell lymphomas linked to EBV.

Dr. Matthew Blake Greenblatt's lab focuses on understanding how specific skeletal stem cells can be harnessed to promote limb regeneration and improve skeletal health. His research aims to discover how these stem cells function in both limb and vertebral regeneration. By studying the mechanisms underlying these processes, his lab hopes to develop innovative therapies for patients suffering from limb loss or spinal disorders.

Dr. Steven Zvi Josefowicz's lab focuses on understanding how a specific histone protein, H3.3, influences the immune system's response to infection and inflammation. They study how varying levels of H3.3 can adjust the activity of genes involved in immune functions, particularly in cells like macrophages and B cells. By exploring these mechanisms, the lab aims to uncover fundamental insights into how immune responses can be finely tuned, which has implications for treating various diseases.

Dr. Jorge Moscat's lab focuses on understanding the mechanisms of mesenchymal colorectal cancer (CRC), a highly aggressive type of cancer with poor outcomes and limited treatment options. They aim to uncover how cholesterol metabolism contributes to the development of this cancer and how specific proteins can regulate this process. The lab combines mouse models and human data to identify new potential therapies for CRC, which may help overcome its challenges in treatment.

Dr. Seung Ha Nam's lab at Weill Medical College focuses on studying blood disorders known as myeloproliferative neoplasms (MPNs), particularly how genetic mutations affect responses to treatment. Using advanced techniques like single-cell sequencing, the lab investigates why some patients respond well to interferon therapy while others develop resistance. By understanding these mechanisms, the lab aims to develop more effective therapeutic strategies for treating MPNs.

David S. Rickman's lab focuses on understanding how prostate cancer evolves from a treatable form into a more aggressive type known as neuroendocrine prostate cancer (NEPC). They investigate the role of specific genes and epigenetic changes during this transformation, aiming to identify new treatments that can prevent or reverse this aggressive evolution. The lab uses patient-derived organoids and genetically engineered mouse models to explore these mechanisms and develop targeted therapies.

Dr. Pengbo Zhou's lab focuses on understanding how specific mutations in the SPOP gene influence the development and progression of prostate cancer. By exploring both upstream regulators and downstream effects of this signaling pathway, the lab aims to identify new treatment strategies that target specific cancer subtypes, particularly those that display unique responses to therapy. This research is crucial for creating more effective, personalized medical interventions for patients with prostate cancer.

Dr. Jingli Cao's lab at Weill Medical College focuses on understanding how zebrafish can regenerate their heart after injury. The lab explores the role of polyploid cells, which have multiple copies of their genome, in the heart's regenerative process. By studying how these cells communicate and lead the healing process, the research aims to uncover new ways to improve heart repair in humans and address diseases associated with polyploidy, like cancer and kidney injury.