Dr. Alfred J Robison's lab at Michigan State University focuses on understanding how innate immune cells called mast cells function in stress and disease. They investigate the genetic and transcriptional mechanisms that regulate these cells, looking for ways to develop new treatments for conditions like allergies, infections, and mood disorders. The lab also studies how stress affects brain circuits, particularly in men and women, to identify sex-specific factors that contribute to resilience in mood disorders.

Dr. Cheryl Rockwell's lab focuses on understanding how dietary additives, specifically tert-butylhydroquinone (tBHQ), affect the immune response to influenza. They aim to uncover the mechanisms behind how tBHQ impairs T cell function, which is crucial for fighting viral infections and achieving effective vaccinations. This research could lead to better predictions about how certain substances in our diets might influence our immunity to diseases.

Dr. Dana Spence's research lab at Michigan State University focuses on understanding Multiple Sclerosis (MS) by examining how interactions between immune cells and the blood-brain barrier affect the disease. The lab develops innovative 3D tissue models and imaging techniques to study the role of hypermetabolic red blood cells and matrix metalloproteinases in MS pathology. This research may contribute to better diagnostic tools and therapies for this condition.

Dr. Kathy Steece-Collier's lab focuses on developing gene therapy techniques to treat levodopa-induced dyskinesia (LID), a painful side effect of Parkinson's disease medications. The lab investigates how silencing specific calcium channels in the brain can help prevent or reverse LID, especially in older patients and those with varying onset ages. Ultimately, the goal is to improve the quality of life for people living with Parkinson’s disease by exploring new therapeutic options for LID.

Dr. Neera Tewari-Singh's lab focuses on understanding the harmful effects of certain chemical agents known as vesicants, like mustard gas and phosgene oxime, specifically how they damage the lungs after skin contact. The lab aims to uncover the role of mast cells in this process, which could lead to new treatment strategies for those affected by these toxic agents. Their research is important for developing therapies for acute and long-term lung injuries caused by chemical exposure.

Dr. Jennifer B Jacob's lab focuses on discovering and targeting genes involved in cancer progression, specifically using mouse models that mimic human cancers. They investigate regulatory genes and their potential as targets for cancer therapies, studying immune responses and intervention strategies to improve treatment outcomes. Through advanced genetic analysis and bioinformatics, the lab aims to enhance our understanding of tumor immunity and develop new cancer treatment approaches.

Dr. Xianshuang Liu's lab focuses on understanding how gut bacteria communication influences diabetic peripheral neuropathy, a serious complication of diabetes. The lab studies small particles called extracellular vesicles, which carry signals between cells and can affect inflammation and nerve health. Their research could lead to new treatments for patients suffering from this painful condition.

Dr. James P. Luyendyk's lab studies how the blood protein von Willebrand Factor (VWF) affects the repair of liver injuries caused by an overdose of acetaminophen, a common pain medication. They aim to discover ways to enhance liver recovery by targeting VWF and its interactions with platelets. The lab works closely with a network of physician-scientists and utilizes advanced genetic models and therapeutic strategies to address acute liver failure, which currently has limited treatment options.

Dr. Dohun Pyeon's lab focuses on understanding how certain viruses, specifically human papillomaviruses (HPV), contribute to the progression of head and neck cancers. They aim to uncover the mechanisms that allow these cancers to evade the immune system, particularly by studying a specific protein that degrades immune receptors, which helps tumor cells escape detection. By targeting these pathways, the lab seeks to develop new immunotherapies that could improve treatment outcomes for patients with HPV-related head and neck cancers.

Dr. Stephanie W Watts' lab at Michigan State University investigates the role of perivascular adipose tissue (PVAT) in maintaining vascular health. The lab aims to understand how PVAT interacts with blood vessels and influences blood pressure regulation, which is crucial for preventing cardiovascular diseases. The research employs a variety of animal models and innovative techniques to explore how physiological changes impact PVAT function and, ultimately, cardiovascular health.

Dr. Zhiyong Xi's lab at Michigan State University focuses on developing innovative strategies to control malaria using Wolbachia-infected mosquitoes. The lab studies how environmental factors and genetics affect the ability of these mosquitoes to block malaria parasites. Their research aims to create new lines of mosquitoes that enhance disease resistance in a sustainable way, contributing to public health efforts against malaria.