Dr. Claudia Fischbach's lab at Cornell University is focused on understanding how the mechanical properties of adipose tissue influence breast cancer, particularly in the context of obesity. The research investigates how changes in adipose tissue and fat cells affect tumor invasion and metastasis. By combining computational models, cell culture techniques, and analysis of human specimens, the lab aims to uncover new insights that could potentially improve patient outcomes in breast cancer.

Dr. Nelly Andarawis-Puri's lab at Cornell University focuses on understanding and treating common tendon injuries known as tendinopathies. The research aims to develop better therapeutic strategies to promote healing and repair through exercise and other interventions in tendon injuries. By investigating the biological mechanisms behind tendon repair and degeneration, the lab seeks to improve diagnostic and treatment options for patients suffering from these conditions.

Dr. Brian Lazzaro's lab at Cornell University studies antimicrobial peptides, which are crucial for defending against bacterial infections. By using the fruit fly model, Drosophila melanogaster, the lab explores how these peptides work and evolve. The goal is to understand their mechanisms in order to design new antimicrobial treatments that target specific pathogens more effectively.

Dr. John D. Helmann's lab at Cornell University studies how bacteria, specifically Bacillus subtilis, respond to stress from both nutrients and antibiotics. They investigate how bacteria manage essential metal ions in the presence of immune responses and how they develop resistance to antibiotics. Their findings contribute to our understanding of bacterial behavior in health and disease, which can help in developing better treatments against pathogenic bacteria.

Dr. Martin Graef's lab at Cornell University studies how cellular aging works, particularly through the lens of autophagy, a process where cells clean out damaged components. Using yeast as a model organism, the lab investigates how different forms of autophagy can affect lifespan and aging. The goal is to uncover new biological mechanisms that could help improve health as we age and might one day inform therapies for age-related diseases.

Dr. Minseok Lee's lab at Cornell University is focused on innovative approaches to treat type 1 diabetes by developing advanced devices for cell delivery. The lab's research aims to create a subcutaneous device that can improve the transplantation of insulin-producing cells while avoiding the need for long-term immunosuppression. This work could lead to safer and more effective therapies for individuals suffering from diabetes.

Dr. John T. Lis's lab at Cornell University focuses on understanding how enhancers and promoters work together to regulate gene expression in the human genome. The team is investigating the role of DNA sequences that control these interactions, which are crucial for understanding how genes are turned on and off in various conditions. By mapping these elements and assessing their functions, they aim to provide insights applicable to both normal biology and diseases.

Dr. Laura C Harrington's lab at Cornell University focuses on understanding mosquito reproductive biology, particularly the Aedes aegypti species, which is a major vector for diseases like dengue, Zika, and chikungunya. The lab investigates specific molecules in male mosquito seminal fluid that affect female behavior and reproductive success, aiming to develop innovative mosquito control methods that target these molecules to decrease disease transmission. By unraveling the complexities of mosquito mating and reproduction, the lab is contributing to the fight against mosquito-borne illnesses.

Dr. Sarah Caddy's lab at Cornell University focuses on understanding how maternal antibodies affect the efficacy of oral vaccines in infants. This research is particularly important for improving rotavirus vaccination strategies, especially in low-income countries where rotavirus causes severe gastroenteritis in children. Through studying both human samples and developing mouse models, the lab aims to uncover the mechanisms behind maternal antibody interference and identify ways to enhance vaccine responses in infants.

Tristan H Lambert's lab at Cornell University focuses on innovative approaches in catalysis to enhance the speed and efficiency of chemical synthesis, particularly for biologically important molecules. The research investigates novel catalytic platforms, such as electrophotocatalysis, and aims to develop next-generation catalysts to facilitate complex reactions. By improving the methodologies in organic synthesis, the lab hopes to overcome obstacles in the discovery of new medicinal agents.

Dr. Shaoyi Jiang's lab at Cornell University focuses on understanding how lipid nanoparticles (LNPs) interact with the immune system. By studying the immunogenicity of these nanoparticles, the lab aims to identify which components of LNPs cause adverse immune responses, particularly in the context of vaccine development. Their research seeks to improve the safety and effectiveness of LNPs used in vaccines and therapeutics.

Jun Liu's lab at Cornell University studies the bone morphogenetic protein (BMP) signaling pathway, which is crucial for proper development and function in organisms. Using the model organism C. elegans, the lab investigates how various proteins and genetic factors regulate BMP signaling and its implications for diseases such as cancer and cardiovascular conditions. Their research aims to uncover the mechanisms behind BMP regulation, which could lead to new therapeutic strategies for disorders related to faulty BMP signaling.

Dr. Mandy Mcgeachy's lab at Cornell University focuses on understanding how specific immune cells called Th17 cells can either protect the body from infections or contribute to autoimmune diseases like multiple sclerosis. The lab studies molecular mechanisms that influence Th17 cell behavior, especially a process called post-transcriptional regulation, which affects how these cells express key proteins involved in inflammation. By uncovering these pathways, the lab hopes to identify new therapeutic targets that can help manage autoimmune conditions.

Dr. Ilana Lauren Brito's lab at Cornell University focuses on understanding how proteins from human hosts interact with those from the microbiome, which are crucial for health and disease. The research is aimed at discovering new protein-protein interactions (PPIs) between hosts and microbiome organisms, using advanced computational models and experimental techniques. This work can lead to insights into microbiome-related disorders and potentially identify new therapeutic targets.

Dr. John S. Parker's lab at Cornell University focuses on understanding viral myocarditis, a heart condition often linked to viral infections, particularly in infants and neonates. The research uses advanced techniques such as single-cell RNA sequencing and spatially resolved transcriptomics to investigate how different cell types in the heart respond to viral infections. This work aims to identify new diagnostic tools and potential treatments for this complex disease.

Dr. B Franklin Pugh's lab at Cornell University investigates how genes are regulated in yeast and humans. By starting with the simpler yeast model, they aim to understand the fundamental mechanisms of gene regulation that apply across all eukaryotic life. Their research focuses on mapping the intricate interactions between proteins and DNA, which can lead to improved diagnostics and therapies for diseases in humans.

Dr. Brian David Rudd's lab focuses on understanding how the immune system, particularly T cells, develops and functions from infancy to adulthood. By studying lymph node responses to infections, the lab aims to create a detailed map of T cell activation and location throughout different life stages. This research can lead to better vaccines and immunotherapies that are tailored to enhance immunity, especially in early life.

The Crane lab at Cornell University focuses on understanding how light and chemical signals influence the behavior of cells, particularly in bacteria and fruit flies. They study key systems that allow cells to move toward certain stimuli, a process crucial for bacteria to cause disease, and also investigate the molecular mechanisms that regulate biological clocks in organisms. By using advanced techniques in biochemistry and structural biology, the lab aims to contribute to our knowledge of diseases that arise when these systems malfunction.

Itai Cohen's lab at Cornell University studies how various sensory systems in the brain interact and work together to help animals navigate their environments. Using fruit flies, they investigate how visual, mechanical, and gyroscopic information are processed to generate movement commands. The lab combines techniques like advanced imaging and computational modeling to understand the neural circuits involved in these processes, contributing to knowledge on motor coordination-related disorders in humans.

Dr. Colleen M. Lau's lab at Cornell University studies the immune system, focusing on a group of cells called natural killer (NK) cells. These cells are unique because they can develop memory, allowing them to respond better to infections over time. The lab investigates how NK cells remember past infections at a molecular level, particularly through changes in the way their DNA is organized and modified. This research aims to develop better strategies for cell-based immunotherapies to treat diseases by enhancing NK cell memory and function.