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Yvonne M. W. Janssen-Heininger — Dr. Yvonne M. W. Janssen-Heininger's lab at the University of Vermont studies lung cancer, focusing on how a molecular process involving a protein called glutaredoxin affects cancer cell survival and resistance to treatment. The lab is investigating how changes in glutathione metabolism can influence lung tumor growth and how these insights can lead to potential new therapies for lung cancer patients. By understanding the cancer's metabolic adaptations, the lab aims to develop strategies to enhance the effectiveness of existing treatments like cisplatin.
Kathleen M Trybus — Dr. Kathleen M Trybus and her lab at the University of Vermont focus on understanding the biology of malaria-causing parasites known as Plasmodium. By studying specific proteins called myosins that help these parasites move and invade host cells, they aim to identify new targets for drug development. This research is crucial for combatting malaria, especially given the recent challenges with vaccine efficacy and drug resistance.
Markus Thali — Dr. Markus Thali's lab at the University of Vermont focuses on understanding how the HIV virus spreads in the body, specifically by studying small clusters of infected T cells called syncytia. These syncytia can form as early as the initial stages of infection and may play a significant role in the virus's ability to infect healthy cells. The lab employs advanced imaging techniques and biological assays to explore the movement and behavior of these syncytia, aiming to uncover new strategies to combat HIV.
Brigitte Lavoie — Dr. Brigitte Lavoie's research focuses on understanding gallbladder diseases, particularly how inflammation and muscle dysfunction in the gallbladder contribute to the formation of gallstones. By investigating the cellular mechanisms that affect gallbladder contraction and researching potential treatments, her lab aims to provide insights that could lead to better management of this common digestive disorder.
Jason W. Botten — Dr. Jason W. Botten's lab at the University of Vermont focuses on understanding how certain viruses, specifically arenaviruses, produce defective particles that can influence both viral infection and host health. The lab investigates the cellular mechanisms that regulate these defective particles and their role in viral persistence within animal hosts, particularly rodents. By exploring these interactions, the research could provide insights into how zoonotic viruses impact public health.
Masayo Koide — Dr. Masayo Koide's lab studies how high levels of the hormone aldosterone can negatively affect small blood vessels in the brain, potentially leading to cognitive issues or dementia. The research focuses on understanding the mechanisms by which this hormone impacts blood flow in very small brain vessels and aims to identify new ways to protect brain health. This work is important for developing strategies to mitigate cognitive decline associated with small vessel diseases.
Matthew Caporizzo — Dr. Matthew Caporizzo's lab focuses on understanding diastolic heart disease (DHD), which affects the heart's ability to relax and is a major health issue worldwide. The research investigates how cardiac microtubules contribute to heart stiffness and impaired relaxation in conditions such as hypertension. By examining the molecular mechanisms behind these processes, the team aims to identify potential new therapies that could help treat DHD.
Osama F Harraz — Dr. Osama F Harraz's lab at the University of Vermont focuses on understanding how blood flow to the brain is regulated and how that process is affected in conditions like hypertension. They study a protein called Piezo1, which acts as a sensor in blood vessel cells, enabling them to respond to changes in blood flow. By examining how this protein functions in different scenarios, the lab aims to identify new strategies for treating cardiovascular diseases that impact brain health.
Benedek Erdos — Dr. Benedek Erdos's lab at the University of Vermont focuses on understanding how stress affects blood pressure and heart health. The research investigates a specific signaling pathway in the brain that can lead to heightened sensitivity to stress, which contributes to the development of hypertension. By studying this mechanism, the lab aims to find new ways to treat high blood pressure that is aggravated by psychological stressors.