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Howard J Edenberg — Dr. Howard J. Edenberg's lab focuses on understanding the genetic factors that contribute to substance use disorders (SUDs). The lab conducts experiments to identify specific genetic variants that affect gene regulation in brain cells, which could lead to significant insights into the mechanisms behind these disorders. Through innovative high-throughput techniques and computational modeling, the lab aims to create a resource of genetic variants that link to SUD risk, thereby paving the way for future prevention and treatment strategies.
Wei Luo — Dr. Wei Luo's lab focuses on developing a universal influenza vaccine by understanding and overcoming immunodominance in B cell responses. They work on novel nanoparticle adjuvants that enhance immune response against less dominant, yet crucial parts of the influenza virus. The research aims to manipulate B cell maturation and antibody diversity to create more effective vaccines against influenza.
Yi Zhao — The research lab led by Dr. Yi Zhao at Indiana University focuses on advancing statistical methods to analyze complex longitudinal data in the context of neuroimaging and mental health. By developing innovative models that take into account various factors such as genetics, environmental influences, and demographic differences, the lab aims to understand brain changes associated with conditions like Alzheimer's disease and the impacts of substance abuse. This work seeks to improve personalized strategies for prevention and intervention, particularly for adolescents and the elderly.
Bruce T Lamb — Dr. Bruce T. Lamb's lab focuses on understanding how genetic variations in the PLCG2 gene influence the biology of microglia, the immune cells of the brain, and contribute to Alzheimer's disease. By studying these variants in mouse models, the lab aims to elucidate their effects on disease progression and identify potential therapeutic targets. This research is crucial for developing new treatments for Alzheimer's disease.
Jeffrey Dage — Dr. Jeffrey Dage's lab focuses on finding new biomarkers for Alzheimer's disease (AD) and related conditions like progressive supranuclear palsy (PSP). By studying different forms of the tau protein in the blood, the lab aims to improve early diagnosis and understanding of these diseases. Their work involves advanced techniques to analyze blood samples from clinical trials, contributing to better detection of tau-related disorders.
Kenneth E White — Dr. Kenneth White's lab focuses on understanding how aging affects muscle and bone health. They are particularly interested in the biochemical pathways that connect muscles, bones, and kidneys, and how these pathways can be influenced by factors like exercise. By investigating the role of specific molecules, such as L-BAIBA and FGF23, the lab aims to identify new therapeutic strategies to improve the quality of life for aging individuals who face issues like sarcopenia and osteoporosis.
Michael Aaron Weiss — Dr. Michael Aaron Weiss's lab focuses on creating and studying new types of insulin that can help treat Type 1 diabetes more effectively and safely. They are particularly interested in how changes in the structure of insulin can improve its function and reduce side effects, such as low blood sugar. The lab uses advanced techniques like cryo-electron microscopy to analyze insulin's behavior and develop analogs that respond to glucose levels in the body, potentially transforming diabetes management.
Ruben Vidal — Dr. Ruben Vidal's lab investigates brain disorders related to tau proteins, particularly tauopathies, which are associated with neurodegeneration. Using advanced imaging techniques, the team studies the structures of tau aggregates and how they influence diseases like progressive supranuclear palsy and new forms of tauopathies. Their research aims to improve understanding of these conditions, which can lead to better diagnoses and treatments.
Jungsu Kim — Dr. Jungsu Kim's lab at Indiana University specializes in understanding the genetic factors that contribute to Alzheimer's disease, particularly focusing on the immune system's role in the disease's progression. By exploring the functions of specific genes in microglia, the brain's immune cells, the lab aims to uncover new therapeutic targets and improve our understanding of this complex disease. Students can expect to engage in cutting-edge research that combines molecular genetics, cellular biology, and advanced imaging techniques.