Dr. Jian Jin's lab focuses on developing new therapeutic strategies for certain types of cancers and Alzheimer's disease. They specifically research targeted treatments for MLL-rearranged leukemias, multiple myeloma, and Alzheimer's disease by inhibiting key enzymes involved in gene regulation. The lab's innovative work aims to create drug candidates that can be used in clinical trials for patients who currently have limited treatment options.

Dr. George W. Huntley's lab focuses on understanding the early cognitive impairments that occur in individuals with Parkinson's disease, specifically how these changes relate to the neurobiology of the brain. The team investigates a mouse model carrying a mutation linked to Parkinson's, exploring the role of cholinergic signaling and how it differs between male and female mice. The goal is to identify potential treatments for cognitive decline in Parkinson's patients and improve diagnosis tools.

Dr. Rachel L Miller's lab focuses on understanding how prenatal and early life environmental exposures affect children's health, particularly concerning asthma and ADHD. The lab's research examines various physical, chemical, and social exposures that may contribute to these conditions, aiming to identify ways to improve prevention, treatment, and intervention strategies for affected children. By utilizing a large population cohort, the lab aims to generate impactful insights that will enhance clinical practices in pediatric health.

Dr. Christopher Sturgeon's lab focuses on understanding how blood cells develop in embryos, particularly how different early cell types contribute to the formation of blood and immune cells. By studying these early developmental processes, the lab aims to improve techniques for generating various blood cell types from stem cells, which could have significant applications in regenerative medicine and treatments for blood disorders. Their work investigates the roles of different cellular programs and signaling mechanisms in hematopoietic development.

Dr. Mone Zaidi's lab focuses on exploring the role of pituitary hormones, particularly follicle-stimulating hormone (FSH), in age-related diseases like osteoporosis, obesity, and Alzheimer's disease. They aim to develop therapeutic antibodies that can block FSH to prevent cognitive decline, bone loss, and obesity. The research combines insights from pharmacology, neuroscience, and bone biology to understand how these hormones affect health in older adults and to push new treatments into human clinical trials.

Dr. Inga Peter's lab at the Icahn School of Medicine focuses on understanding the mechanisms behind kidney disease and accelerated aging in people living with HIV (PWH). With a special emphasis on genetic factors that increase the risk of end-stage kidney disease, the lab is also investigating how epigenetic changes and clonal hematopoiesis can impact health outcomes in older PWH. The ultimate goal is to develop new strategies for prevention and treatment that improve the healthspan of individuals living with HIV.

Dr. Roger L. Clem's lab focuses on understanding how the brain processes conflicting memories of threat and safety, particularly through the role of specific neurons in the hippocampus. The research aims to uncover mechanisms behind fear memory extinction, which is essential for overcoming trauma. By studying these processes, the lab hopes to contribute insights that can improve therapeutic approaches for individuals dealing with pathological fear, such as those suffering from anxiety and PTSD.

Dr. Denise Jade Cai's lab at the Icahn School of Medicine focuses on understanding how our memories are linked together, especially how strong negative experiences can change the way we recall past neutral events. They study the brain circuits involved in memory using advanced techniques like imaging and optogenetics in mice. The research aims to shed light on how these memory processes might influence behavior, particularly in the context of anxiety and trauma.

Dr. Alison Goate's lab at the Icahn School of Medicine focuses on understanding the role of microglia in Alzheimer's disease. They are investigating how specific genes and signaling pathways in these immune cells can protect against neurodegeneration and how dysfunctional activation of microglia might contribute to the progression of the disease. The ultimate aim is to identify therapeutic targets that could prevent or delay the onset of Alzheimer's disease.

The Maze lab conducts innovative research to understand how specific molecular mechanisms in the brain contribute to mental health disorders, particularly mood disorders like depression and conditions such as Down syndrome. By studying post-translational modifications of proteins that affect gene expression, the lab seeks to uncover new therapeutic targets and insights into the regulation of brain function and dysfunction. Their work combines advanced techniques in molecular biology, genetics, and behavioral analysis to address complex neurological challenges.

Dr. Alan C Seifert's lab investigates how COVID-19 affects the brain, particularly in patients who experience ongoing neurological issues after recovering from the virus. This condition, known as neuroPASC, can include symptoms like memory problems, fatigue, and mood disorders. The lab uses advanced MRI techniques to study brain damage and aims to uncover the underlying mechanisms of this syndrome to aid in developing targeted treatments.

Prashanth Rangan's lab focuses on understanding the important transition from germ cells to mature egg cells (oocytes), which is crucial for fertility. They use Drosophila, a type of fruit fly, as a model organism to explore how specific genes are silenced during this process to ensure the proper development of embryos. This research aims to uncover mechanisms that could lead to new insights into human infertility.

Dr. Yasmin L. Hurd's lab focuses on understanding opioid use disorder, particularly how heroin affects the brain at a molecular level. The team combines human and animal studies to explore the neurobiological changes caused by opioids, aiming to identify new treatment options for addiction that avoid the risks of traditional opioid-based medications. By investigating specific pathways involved in addiction, they hope to develop targeted therapies that can better aid individuals struggling with opioid dependence.

Dr. Stuart C. Sealfon's lab at the Icahn School of Medicine focuses on understanding the pituitary gland's role in the endocrine system by studying the molecular changes occurring in its different cell types. Using cutting-edge single cell technologies, the lab investigates how these cells adapt during normal physiological processes and diseases like hypothyroidism. Their research aims to reveal insights into gene regulation and cell behavior, contributing to our understanding of overall health and disease dynamics.

Dr. Ki Ann Goosens leads a research lab focused on understanding how chronic stress affects decision-making processes in the brain. The lab studies the interactions between specific brain circuits and hormones like ghrelin, which play vital roles in determining how we weigh potential risks and rewards. Through innovative approaches such as optogenetics and pharmacological experiments, they aim to uncover the mechanisms that lead to altered decision-making in the context of psychiatric disorders such as depression and PTSD.

Dr. Guo-Cheng Yuan's lab focuses on understanding the complex interactions between different cell types within tissue environments and how these interactions change during development, aging, and disease progression. The lab uses advanced spatial transcriptomics techniques to analyze the structural organization of tissues, specifically looking at the changes that occur during acute kidney injury. By developing new computational frameworks, they aim to produce powerful tools for researchers and clinicians to better investigate these vital areas of health and disease.

Dr. Goran Bajic's research lab focuses on understanding how our immune system responds to vaccines and infections, especially in the context of evolving viruses like SARS-CoV-2. The lab utilizes advanced techniques to study B cells, which play a crucial role in producing antibodies. By analyzing how these immune responses develop at a molecular level, the lab aims to improve vaccine design and enhance our capacity to fight rapidly changing pathogens, including various coronaviruses.

Dr. Adolfo Garcia-Sastre's lab at the Icahn School of Medicine focuses on studying how viruses, particularly SARS-CoV-2 and other coronaviruses, adapt to human hosts. By utilizing systems biology approaches and advanced modeling techniques, the lab aims to uncover biological networks that influence viral replication and disease severity. Their research seeks to identify potential biomarkers and therapeutic targets that can help in predicting disease outcomes and developing new treatments.

Dr. Jeffrey R. Johnson's lab focuses on understanding how viruses like HIV-1 and SARS-CoV-2 manipulate human cells during infection. The research aims to uncover the mechanisms by which these viruses degrade host proteins to enhance their replication and to identify potential therapeutic targets for treating viral infections. Through various molecular and genetic techniques, the lab strives to advance our understanding of viral biology and contribute to the development of new antiviral therapies.

Dr. Ana Fernandez-Sesma's lab focuses on understanding the human immune response to various viral infections and vaccinations, specifically SARS-CoV-2, seasonal influenza, and dengue viruses. The lab conducts comprehensive studies using advanced techniques to analyze immune system responses before and after vaccination, utilizing data from different human cohorts. By leveraging cutting-edge genomics and immunological profiling methods, the lab aims to generate valuable insights into vaccine effectiveness and immune memory.