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Daniel J Wozniak — Dr. Daniel J. Wozniak's lab at Ohio State University focuses on understanding the complex relationships between harmful bacteria and how they affect chronic infections, particularly in patients with cystic fibrosis. By studying the interactions between two common pathogens, Pseudomonas aeruginosa and Staphylococcus aureus, the lab aims to develop new treatments using bacteriophages, which are viruses that can kill bacteria. The goal is to find better ways to treat difficult-to-heal infections, especially those resistant to traditional antibiotics.
Amal O Amer — Dr. Amal O. Amer's research lab focuses on understanding the immune response and disease mechanisms related to viral infections and neurodegenerative diseases. The lab's major projects examine the role of specific immune pathways in COVID-19 and Alzheimer's disease, as well as how immune cells respond to infections like Legionella. By investigating the underlying biological processes, the lab aims to identify new therapeutic targets for treating these complex diseases.
Maria M. Mihaylova — Dr. Maria M. Mihaylova's research lab at Ohio State University focuses on understanding how aging affects cancer metabolism. Her team studies the metabolic changes in tumors and their surrounding environments as people age, with the goal of discovering new insights into cancer initiation and progression. By using advanced techniques to analyze single cells, they aim to uncover how diets and microbiome metabolites influence these processes, potentially transforming how we treat cancers in older individuals.
Jeff Kuret — Dr. Jeff Kuret's lab at Ohio State University focuses on understanding tau aggregates, which play a crucial role in Alzheimer's disease and related conditions. The research explores how tau proteins misfold and form unique structures that contribute to neurodegeneration. By studying these aggregates, the lab aims to develop better diagnostic tools and therapies for tauopathies by clarifying the molecular mechanisms involved in tau aggregation and how they can be targeted by small molecules.
Nicholas C. Denko — Dr. Nicholas C. Denko's lab focuses on improving treatments for non-small cell lung cancer (NSCLC) by addressing the challenge of tumor hypoxia. They explore how reducing oxygen demand in tumors can enhance the effects of existing therapies like radiation and immunotherapy. The lab investigates novel derivatives of papaverine, an FDA-approved drug, to assess their potential in overcoming resistance to these treatments.
Karl H Obrietan — Dr. Karl H. Obrietan's lab focuses on understanding how circadian rhythms affect brain functions, particularly in areas related to mood, memory, and decision-making. They investigate how the brain's internal clock interacts with different brain circuits and how disruptions in this timing can lead to neurological disorders. By using innovative techniques, including advanced imaging and genetic models, the lab aims to uncover the biological mechanisms behind these processes and their implications for treatment.
Christin E Burd — Dr. Christin Burd's lab at Ohio State University studies how specific mutations in the NRAS gene lead to various types of cancer, focusing primarily on melanoma and other malignancies. The lab examines the unique biochemical behaviors of different NRAS mutant proteins, seeking to understand how these differences affect tumor growth and response to treatments. By leveraging a combination of structural biology and experimental approaches, the lab aims to identify potential new therapeutic targets for RAS-driven cancers.
Benjamin M Segal — Dr. Benjamin Segal's lab focuses on understanding and treating progressive forms of multiple sclerosis (PMS) and promoting nerve regeneration in the optic nerve. His research investigates the role of specific immune cells in driving neuroinflammation and potential therapies to enhance recovery from nerve injuries. This work aims to reduce disability in older adults suffering from PMS and to develop new treatments for individuals facing vision loss due to optic nerve damage.
Haitao Wen — Dr. Haitao Wen's lab at Ohio State University focuses on understanding how a specific type of cell death, called ferroptosis, can be induced in cancer cells. The lab investigates how mitochondrial calcium signaling affects this process, especially in cancers that resist traditional therapies. By exploring the connections between cell death and immune response in tumors, the research aims to identify new ways to enhance cancer treatment.