Dr. Christopher Browning's research lab investigates how everyday environments influence the health and development of adolescents, particularly focusing on stress and safety perceptions. The lab studies the role of community violence and a sense of belonging in shaping psychological well-being and physical health outcomes for young people. By using advanced data collection methods, including GPS tracking and physiological measurement, the team aims to better understand these influences and their implications for public health.

Dr. Baldwin M Way's lab at Ohio State University investigates the relationship between passive social media use and mental health in adolescents. The lab focuses on understanding how observing others on social media, without direct interaction, affects young people's emotional wellbeing, particularly in varying stressful environments. By combining surveys and physiological measurements, the lab aims to uncover the biological processes linking social media habits and mental health outcomes.

Dr. Sujit Basu's research lab at Ohio State University focuses on advancing cancer treatment through immunotherapy. They specifically study the blockade of the CD200R pathway, which affects immune cell behaviors in the tumor environment. By understanding how to manipulate immune responses, Dr. Basu's team aims to improve the effectiveness of cancer therapies, potentially enhancing the way we treat various malignancies.

Dr. Marco Brocanelli's research lab focuses on developing innovative solutions to improve outdoor navigation for people with visual impairment (PVI). By creating a mobile framework called VisionWay, the lab aims to evaluate and provide accessible path recommendations, taking into account real-world sidewalk conditions like potholes and obstructions. The project leverages technological advancements and insights from individuals with lived experience of visual impairment to enhance wayfinding tools.

Dr. Christin Burd's lab at Ohio State University studies how specific mutations in the NRAS gene lead to various types of cancer, focusing primarily on melanoma and other malignancies. The lab examines the unique biochemical behaviors of different NRAS mutant proteins, seeking to understand how these differences affect tumor growth and response to treatments. By leveraging a combination of structural biology and experimental approaches, the lab aims to identify potential new therapeutic targets for RAS-driven cancers.

Dr. Brandon Biesiadecki's research focuses on improving heart function in diseases where the heart cannot pump enough blood to meet the body's needs. He studies a specific modification of heart muscle proteins that enhances contraction without increasing calcium levels, which could lead to fewer side effects than current treatments. The goal is to develop new therapies that can safely enhance heart performance without the risks associated with traditional medications.

Isabelle Deschenes' lab at Ohio State University focuses on understanding the mechanisms underlying sudden cardiac death, particularly in heart failure patients. They investigate the roles of specific proteins like KChIP2 and JNK2 in heart cell communication and rhythm management. By exploring these pathways, the lab aims to discover new therapeutic strategies to prevent dangerous heart rhythms and improve patient outcomes.

Dr. Krishna Chinthalapudi's lab at Ohio State University focuses on understanding how proteins in the heart, particularly cardiac myosin and its binding partner cMyBP-C, control muscle contraction. This research aims to uncover the molecular mechanisms behind these proteins, which is crucial for developing new treatments for heart diseases like cardiomyopathy. By exploring the structural states of cardiac myosin, the lab hopes to shed light on how these processes affect heart function and could lead to innovative therapies.

Dr. Daniel J. Wozniak's lab at Ohio State University focuses on understanding the complex relationships between harmful bacteria and how they affect chronic infections, particularly in patients with cystic fibrosis. By studying the interactions between two common pathogens, Pseudomonas aeruginosa and Staphylococcus aureus, the lab aims to develop new treatments using bacteriophages, which are viruses that can kill bacteria. The goal is to find better ways to treat difficult-to-heal infections, especially those resistant to traditional antibiotics.

Dr. Haitao Wen's lab at Ohio State University focuses on understanding how a specific type of cell death, called ferroptosis, can be induced in cancer cells. The lab investigates how mitochondrial calcium signaling affects this process, especially in cancers that resist traditional therapies. By exploring the connections between cell death and immune response in tumors, the research aims to identify new ways to enhance cancer treatment.

Dr. Angela Filous's lab at Ohio State University focuses on understanding how infections, particularly pneumonia, impact recovery after spinal cord injuries. They explore the mechanisms behind impaired recovery and aim to find ways to protect spinal cord function in patients. The lab uses various experimental models to investigate the cellular and molecular interactions involved in injury and repair processes following infection.

Dr. Deliang Guo's lab at Ohio State University focuses on finding new treatment strategies for glioblastoma (GBM), an aggressive brain tumor. The research explores how GBM cells utilize lipids and glutamine for growth and survival, aiming to disrupt these processes to develop effective therapies. By studying lipid metabolism and testing new drug combinations, the lab hopes to identify safer and more effective ways to treat this challenging disease.

Dr. Karin M. Musier-Forsyth's lab at Ohio State University focuses on understanding how the HIV-1 virus packages its RNA and how this process affects viral replication and function. The research investigates the role of different RNA structures produced from the virus's genetic material and how these structures interact with host factors during viral assembly and translation. Findings aim to inform the development of new therapies against HIV.

Dr. Shuiying Hu's lab at Ohio State University focuses on understanding how the chemotherapy drug vincristine causes damage to peripheral neurons and finding ways to prevent this neurotoxicity. The lab studies how vincristine is taken up by neurons through specific transporters and aims to develop drugs that can protect these neurons while still allowing vincristine to effectively target cancer cells. Their research could lead to safer cancer treatments with fewer side effects for patients.

Dr. Jeff Kuret's lab at Ohio State University focuses on understanding tau aggregates, which play a crucial role in Alzheimer's disease and related conditions. The research explores how tau proteins misfold and form unique structures that contribute to neurodegeneration. By studying these aggregates, the lab aims to develop better diagnostic tools and therapies for tauopathies by clarifying the molecular mechanisms involved in tau aggregation and how they can be targeted by small molecules.

Dr. Sharon Amacher's lab at Ohio State University focuses on understanding how rhythmic patterns of gene expression, known as biological oscillators, regulate important developmental processes. Their research explores these oscillators' roles in processes like organ development and cellular differentiation, especially during the formation of somites, which are essential for building vertebrate body structures. By studying various model organisms, they aim to uncover the genetic and molecular mechanisms behind these oscillatory patterns, contributing to our knowledge of developmental biology and stem cell regulation.

Dr. Vladimir M. Sloutsky's lab focuses on understanding how young children develop their language skills and the ability to categorize information. Through various studies with children aged 4 to 9, the lab explores how exposure to language and statistical patterns influences semantic organization and comprehension. The research aims to provide insights that can help in diagnosing and treating developmental disabilities related to language and categorization skills.

Dr. Dana Mctigue's lab at Ohio State University focuses on understanding how spinal cord injuries (SCI) impact liver health and metabolic functions. The research aims to uncover the mechanisms behind liver disease, specifically non-alcoholic fatty liver disease, in individuals with SCI and to find ways to improve their overall metabolic health. By studying the interactions between the nervous system and liver, the lab aims to identify potential therapies that could enhance recovery and reduce complications in spinal cord injury patients.

Dr. Maria M. Mihaylova's research lab at Ohio State University focuses on understanding how aging affects cancer metabolism. Her team studies the metabolic changes in tumors and their surrounding environments as people age, with the goal of discovering new insights into cancer initiation and progression. By using advanced techniques to analyze single cells, they aim to uncover how diets and microbiome metabolites influence these processes, potentially transforming how we treat cancers in older individuals.

Dr. Dmitry Terentyev's lab at Ohio State University focuses on understanding how mitochondrial dysfunction leads to dangerous heart rhythm problems. They study the relationship between mitochondria, calcium signaling, and heart health, particularly under stress. The lab aims to find ways to improve heart function and reduce the risk of fatal arrhythmias, especially in patients with specific genetic conditions or heart diseases.